Genxi Bio will announce the latest research results of BCMA/CD19 dual-target CAR-T cell therapy GC012F based on FasTCAR platform in the treatment of relapsed/refractory multiple myeloma at ASCO Annual

Suzhou, China, Palo Alto, California, USA May 20, 2021/PRNewswire/-Genxi Biotechnology Group (NASDAQ: GRCL;; Genxi Bio, a global clinical biopharmaceutical company dedicated to developing efficient and economical cell therapy for cancer treatment, announced today that it will publish the latest clinical research results of a multi-center, first-time human trial on GC012F in the treatment of relapsed/refractory multiple myeloma during the annual meeting of American Society of Clinical Oncology (ASCO) in 2021 and the conference of European Hematology Association (EHA) in 2021.

GC012F is a BCMA/CD19 dual-target autologous CAR-T cell therapy developed based on the patented technology platform of Genxi Bio-FasTCAR, which has the advantage of "production can be completed the next day". At present, the candidate product is being evaluated in a phase I clinical trial initiated by researchers.

  • By January 12, 2021, 19 patients with multiple myeloma were enrolled in the three dose groups of this study, of which the highest dose level was 3×10.fiveCells/kg body weight, all the above patients meet the criteria of recurrence/refractory after multiple rounds of treatment. Subsequent patients (after the release of data at the ASH annual meeting in 2020) received the highest dose level of treatment.
  • The early objective remission rate (ORR) was as high as 94.7%(18/19), and all the responses showed that excellent partial remission (VGPR) and even complete remission (SCR) were obtained. The data of all dose groups showed a rapid, in-depth and lasting therapeutic effect.
  • All patients (n=9) who received treatment in the highest dose group achieved negative minimal residual lesions-complete remission (MRD- sCR) in a strict sense.
  • Of the 19 patients, 18 (94.7%) belonged to the high-risk patients defined in mSMART 3.0 guidelines, and the median number of previous treatment lines was 5.
  • 94.7%(18/19) patients have been exposed to PI, IMiD and at least the third treatment scheme, including anti-CD38 targeted therapy.
  • The safety of GC012F is consistent with the previous observation results, and the main symptom is low-grade cytokine release syndrome (CRS)(84% patients are grade 1/2; 11% (n=2) patients were grade 3), and there was no grade 4 or 5 CRS;. No immune effector cell-related neurotoxicity (ICANS) was observed in 19 patients. Adverse events (TEAEs) occurred during treatment were mainly manifested as decrease of blood cell count and increase of AST. All TEAEs were relieved after standard treatment.
  • The study will continue to evaluate the effectiveness and safety of GC012F in the treatment of patients.

"I am glad to see the mutual evidence between the follow-up of the initial patients and the treatment effect of the subsequent patients, which not only confirms the research results announced at the annual meeting of ASH last year, but also further clarifies the excellent safety and effectiveness of GC012F dual-targeted autologous CAR-T cell therapy, including for high-risk patients."Chief Medical Officer of Genxi BiologydoctorIt said: "High-risk patients are usually extremely difficult to treat, but all patients in the highest dose group in this study have reached the MRD negative sCR state and maintained a deep response for six months or even longer after receiving GC012F infusion. The above exciting research data bring brand-new hope to high-risk patients (including those who do not respond to the standard treatment plan). Next, we plan to promote this research on a global scale, including promoting it as a more preferred treatment option. I look forward to sharing more developments with you in the near future. "

GC012FClinical research initiated by researchers (IIT) Co-principal researcher, Professor Du Fu of shanghai changzheng hospital."Multiple myeloma (MM) is a malignant blood tumor that is extremely difficult to treat. There are about 750,000 patients with multiple myeloma worldwide.[1]There are about 160,000 new patients every year.[2]And it is on the rise year by year. Among them, high-risk patients account for 20%-30%.[3]The prognosis is usually poor, accompanied by higher risk of early recurrence, shorter progression-free survival and overall survival. This time, we are pleased to see that the BCMA/CD19 dual-target autologous CAR-T cell therapy GC012F of Genxi Bio has shown excellent effectiveness and safety for the long-term follow-up results of patients with relapsed/refractory multiple myeloma. And thanks to the advantages of FasTCAR platform, the waiting time of clinical treatment has been significantly shortened, and the hope of life has been ignited for more patients. "

GC012FClinical research initiated by researchers (IIT) Co-principal researcher, Professor Fu Weijun of shanghai changzheng hospital.Said: "I am very happy to see that after we announced the first human trial data of GC012F in the form of oral report at the ASH meeting last year, this research has made positive progress again, and the previous results have been further verified; This also allows us to see the good application prospects of Ganxi Bio-FasTCAR platform and Dual CAR technology. With the deepening of research, the clinical benefits of this innovative BCMA/CD19 dual-targeted autologous CAR-T cell therapy for patients with multiple myeloma, especially high-risk patients, are constantly emerging. It is expected that this research will continue to achieve more results and strive to meet the urgent treatment needs of patients with recurrent/refractory multiple myeloma as soon as possible. "

Details of the electronic poster are as follows:

2021American Society of Clinical Oncology (ASCO) annual meeting

abstract8014Long-term follow-up results of the first multicenter human trial of BCMA/CD19 dual-target CAR-T cell therapy GC012F for patients with relapsed or refractory multiple myeloma based on FasTCAR platform.

Poster release date:June 4, 2021

2021European hematology association (EHA2021) conference

abstractEP962Long-term follow-up results of the first multicenter human trial of BCMA/CD19 dual-target CAR-T cell therapy GC012F for patients with relapsed or refractory multiple myeloma based on FasTCAR platform.

Poster release date:June 11th, 2021

About multiple myeloma

Multiple myeloma (MM) is the third most common malignant hematological tumor in the United States. Its tumor cells originated from bone marrow plasma cells, an immune cell responsible for secreting anti-infective antibodies. About 160,000 patients worldwide are diagnosed with multiple myeloma every year; In 2020, the United States is expected to have more than 32,000 confirmed patients. In recent years, although many progress has been made in the treatment of multiple myeloma, the clinical treatment effect is still unsatisfactory. International Myeloma Working Group (IMWG) and the consensus guidelines of Mayo ST Rating for Myeloma and Risk-Adapted Therapy (MSMART) classify patients with specific cytogenetic abnormalities or other abnormalities as high-risk patients, and this group accounts for 20-30% of all patients with multiple myeloma. High-risk patients with high risk of early recurrence, progression-free survival and short overall survival are considered as the most difficult patients with multiple myeloma, and usually have poor prognosis.

aboutGC012F

GC012F is a candidate product for dual-target autologous CAR-T therapy based on FasTCAR platform. At present, the candidate product is evaluating its safety and effectiveness in the treatment of multiple myeloma in a multi-center and phase I clinical trial initiated by researchers, covering many research centers in China. GC012F brings rapid, in-depth and lasting therapeutic effects to patients with multiple myeloma by simultaneously targeting the malignant plasma cell site expressing BCMA and the early progenitor cell site expressing CD19. 

aboutFasTCAR

FasTCAR is a technology platform with intellectual property rights of Genxi Bio, aiming at developing high-quality autologous CAR-T cell therapy. Preclinical studies show that the phenotype of CAR-T cells produced by FasTCAR technology platform is younger, the degree of depletion is lower, and the amplification ability, persistence, bone marrow migration ability and tumor cell clearance activity are enhanced. With the advantage of "completing production the next day", FasTCAR platform technology can greatly improve cell production efficiency, thus significantly reducing production costs and enabling cell therapy to benefit more cancer patients.

About genxi creatures

Genxi Biotechnology Group (Genxi Bio for short) is a global clinical biopharmaceutical company dedicated to the discovery and development of breakthrough cell therapy. Using its pioneering FasTCAR and TruUCAR technology platforms, Genxi Bio is developing a number of rich clinical cancer treatment product pipelines, both autologous and allogeneic. These products are expected to overcome the persistent major industry challenges of traditional CAR-T therapy, including long production time, poor production quality, high treatment cost and lack of effective treatment for solid tumors. To learn more about Genxi Bio, please visit www.gracellbio.com/ Concern LinkedIn account @GracellBio.

Warning statement about forward-looking statements

The statement in the press release about future expectations, plans, prospects and other non-historical facts may contain a "forward-looking statement" as defined in the Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements related to the expected transaction and completion time of this offering. These statements may, but do not necessarily, contain the following words and corresponding negative forms or similar words: purpose, expectation, belief, estimation, prediction, plan, possibility, prospect, plan, potential, conjecture, formulation, seeking, possibility, should and will. Due to various important factors, the actual results may be significantly different from the forward-looking statements, and there is no guarantee that any forward-looking statements will be realized. These important factors include the factors mentioned in the Risk Factors section of Genxi Bio’s recent annual report in Form 20-F, and the discussion on potential risks, uncertainties and other important factors in Genxi Bio’s subsequent report to the US Securities Regulatory Commission after the session. Any forward-looking statements in this statement only reflect the current expectations, and Genxi Bio has no responsibility to publicly update or review any forward-looking statements, whether based on new information, future events or other reasons. Readers are requested not to rely on forward-looking statements after the publication date of this press release.

Media contact


marvin.tang@gracellbio.com

Investor contact

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Haval Xiaolong in Quanzhou has greatly reduced its price! The special price is 129,800, and the car is sufficient.

Recently, car home Quanzhou preferential promotion channel has brought a wave of good news! This popular SUV model is undergoing a price reduction promotion in Quanzhou, with a maximum discount of 10,000 yuan. Now buy Haval Xiaolong, the minimum starting price is only 129,800 yuan. If you are interested in this model, don’t miss this rare preferential opportunity. Please click "Check the car price" in the quotation form to get a higher discount!

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Haval Xiaolong is a stylish and dynamic SUV with a streamlined front face and a black honeycomb grille. The overall style is very sporty. The body lines are smooth and strong, and the body lines are simple and smooth, which is very atmospheric. At the same time, Haval Xiaolong also uses the headlight group of LED light source, which has excellent lighting effect and improves the safety of driving at night. The side of the car body adopts a double waistline design, which highlights the sense of movement and strength of the car body. The tail design is simple, and the taillight group adopts LED light source, so the overall shape is very fashionable. Generally speaking, the design of Haval Xiaolong is excellent, fashionable and dynamic, showing the personality and pursuit of modern young people.

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Haval Xiaolong is a compact SUV with a body size of 4600*1877*1675mm and a wheelbase of 2710 mm. The body lines are smooth and the side lines are simple and atmospheric, which highlights the fashion sense of the car. The front and rear wheel tracks are 1583mm and 1587mm respectively, and the front tyre size is 225/60 R18, and the rear tyre size is also 225/60 R18. The rim of the car body has a unique style and adopts a fashionable shape, which adds a lot of sense of movement to the car. Whether you are driving in the city or traveling long distances, Haval Xiaolong can provide you with an excellent driving experience.

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Haval Xiaolong’s interior design is fashionable and simple, with black as the main tone and metal decoration, which highlights the sense of technology and luxury. The steering wheel is made of leather material, which feels comfortable and can be manually adjusted up and down and back and forth to facilitate the driver’s operation. The central control screen size is 12.3 inches, which supports voice recognition control system, and functions such as multimedia, navigation, telephone, air conditioning, skylight and window can be controlled by voice. The front row and the rear row are equipped with a USB/Type-C interface, which is convenient for passengers to charge. The seat is made of imitation leather. The main driver’s seat can be adjusted in front, back and height, the co-pilot’s seat can be adjusted in front, back and back, and the rear seat supports proportional reclining, providing more space and comfort for passengers.

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Haval Xiaolong uses a 1.5L 101 horsepower L4 engine with a maximum power of 74kW and a maximum torque of 132 N m.. At the same time, it is equipped with a 2-speed DHT gearbox to provide smooth power output and efficient fuel economy for vehicles.

Thanks to the owner of car home for sharing, his/her evaluation of Haval Xiaolong is very pertinent. As a person with a family, he/she attaches great importance to the practicality of vehicles. Haval Xiaolong’s spacious and comfortable space really brings a good car experience to his/her family. In addition, he/she also mentioned his/her love for the appearance and interior of the vehicle, which is one of the reasons for choosing Haval Xiaolong. Haval Xiaolong’s sleek appearance and high-tech interior have left a deep impression on him/her. Moreover, he/she also mentioned that the cost of using Haval Xiaolong is very low, which is also an important factor he/she considers when buying a car. Haval Xiaolong’s low fuel consumption and low maintenance cost make him/her very satisfied. Generally speaking, Haval Xiaolong is a cost-effective model, which not only has excellent exterior and interior design, but also has excellent practicability and use cost.

In the face of high-performance luxury pickup trucks and mountain guns, I just want to say: how much is it, let me give up!

Original title: In the face of high-performance luxury pickup guns, I just want to say: How much is it, let me give up!

"Make China pickup trucks popular all over the world" is a declaration and a goal. The rise of the Great Wall Cannon is unstoppable, and the evolution of the Great Wall Cannon is unstoppable. The Chengdu Auto Show, the first show of the Great Wall Gun’s large-scale high-performance luxury pickup truck Shanhai Gun in the world, is enough to explain everything. Not only that, the innovative pickup truck models such as the New Farmer Edition of King Kong Gun, the Firebomb Rage Qingqi, and the high-end customized version of the Great Wall Gun RV were all present, and the booth of the Great Wall Gun became different again.

Return to position c, shanhai cannon.

When you listen to it, there is a sense of the atmosphere of mountains and rivers. Mountains and seas are not just simple meanings of mountains and seas. In China culture, we can easily associate them with The Classic of Mountains and Seas, which is called an encyclopedia, while the Classic of Mountains and Seas and China culture can be called treasures. So what does it mean to the Great Wall Gun?

The Great Wall has always been highly accomplished in naming cars, and the name of Shanhai Gun is also the result of global collection and user creation, as the official said, but the author also believes that it contains more culture and spirit. Of course, it is difficult to achieve much by indulging in some nihilistic imagination, so Shanhai Gun not only has this name, but also has great achievements in product strength.

High performance. Shanhai Gun comes from the intelligent professional off-road tank platform, and is equipped with China’s strongest and world-leading high-performance 3.0T V6+9AT power system. Its powerful outdoor off-road capability can be seen. More importantly, the whole system of Shanhai Gun comes standard with Borgwarner 4A+LOCK four-wheel drive system. There is nothing to fear between mountains and seas, mountains and rivers, and then we wait for the name of Shanhai Gun to resound through the earth. At the same time, Shanhai Cannon will also launch a model equipped with 2.4T diesel and 2.0T gasoline HEV power combination, with comprehensive coverage and ultimate experience. If it is not the name of mountains and seas, who can issue the declaration of "crossing mountains and seas and exploring the ultimate life"?

Super luxury. Power is strong, luxury is real. Shanhai cannon and luxury are first reflected in the advanced business cockpit. Perhaps no one thought that a pickup truck actually has an extremely luxurious cockpit, so that users can reach the ultimate driving experience of the leapfrog SUV. Secondly, it also has the function of electric welcome adjustment in the back row, which is the first in the world. In addition, the NVH ultra-quiet experience in the back row has also performed extremely well under the blessing of many innovative patented technologies. In addition, there are increased holdings of high-level intelligent driving assistance, fully automatic parking and other technological configurations. The sense of luxury and self-confidence presented by Shanhai artillery seems to be handy, and I can’t help but think of that sentence: the so-called luxury is only familiar.

Super fun. If a pickup truck is easy to use, then fun is the sublimation of product strength. The ever-changing expansion space of Shanhai Gun conveys a super-fun attitude. Relying on the first design of split+flat tailgate in China, Shanhai Gun is turned into a convenient pickup truck model that can cope with multi-scene use. The first is the spatial layout of the three-door trunk, which is flexible and changeable, and can be adjusted and disassembled at will. Secondly, 18 matrix anchors are reserved in the trunk, leaving enough space for subsequent trips, modifications and other ways to play with cars.

At this point, the ultimate three products of Shanhai Gun are presented one by one-"high performance, super luxury and super fun". The disappearance of Shanhai Cannon represents the masterpiece of category innovation in the era of Great Wall Cannon 2.0, and at the same time fills the gap of high-performance category of pickup trucks in China. Therefore, both the brand Great Wall Gun and the model Shanhai Gun have different meanings here.

The all-round display of product strength can attract a large number of users, coupled with the presentation of its mountain and sea culture, is a more perfect mountain and sea cannon. Inciting pickup truck culture with mountain and sea culture is also the core of mountain and sea artillery.

Shanhai Gun is consistent with many models of the Great Wall, and also insists on creating user brands with users. So this time, many life players were invited to witness the appearance of Shanhai Gun, including the paraglider Abu and the "goddess of waterinfo" He Haohao. These two have something in common with Shanhai Gun, and both have the spirit of daring to challenge, pursuing the ultimate and constantly exploring, and the root of Shanhai culture lies in this.

At the same time, Shanhai cannon not only uses KOL’s gimmicks to create momentum, but will be recognized by the market together with the general public. In the future, we will recruit 100 mountain and sea culture co-creation officials on global platforms such as TikTok and the Great Wall Gun APP to realize the concept of "the ultimate life of mountain and sea" and achieve the goal of creating mountain and sea culture and sharing the ultimate life.

Finally, I want to say, "This is the worst time and the best time." This sentence is suitable for the Great Wall Gun brand. It started in the era of banning pickup trucks, but it went to the world as the first high-end pickup truck brand in China that broke through 300,000 units, and it only took three years from the 1.0 to 2.0 era. That sentence makes "China pickup trucks popular all over the world!" It’s really not just a slogan, but a constant breakthrough at the speed visible to the naked eye. Finally, I returned to the theme to ridicule, Shanhai cannon is so excellent, how much is it, let me give up!

Editor in charge:

Starting less than 130,000, the Great Wall Cannon car-class pickup truck went on the market.

  When it comes to pickup trucks, many people will think of camping conventions, desert challenges, cruises around the city and other projects, and this is also a pickup truck feast that many pickup truck owners enjoy. With the continuous enrichment of China’s material culture, in the pickup truck market, a group of people have gradually emerged, far away from the hustle and bustle of the city, driving pickup trucks to "have fun", forming a pickup truck culture and even a pickup truck community in nature.

  

  Moreover, pickup trucks are in line with the emerging cultural tourism culture in recent years, and all kinds of go on road trip infrastructure services for pickup truck owners have also become new business cards of the city. Great Wall Motor, which started as a pickup truck in China, has also "sniffed" this business opportunity for a long time. Its Great Wall Gun (parameter picture) is a brand that has brought the pickup truck culture in China to the extreme, and it is constantly sought after by the high-end market.

  

  Recently (March 12), the global version of the newly upgraded Great Wall gun pickup truck was launched, with the price range of 126,800-166,800 yuan. At this conference, Great Wall Gun also reached a strategic cooperation with China canoeing national team and Pathfinder brand to jointly build the "strongest ecological circle" of pickup truck culture.

  It is worth noting that compared with the original model, the price of the new car has not increased, which further improves the cost performance. However, in terms of configuration, it has increased the heating of the rear seat, the thickening of the engine guard plate, and the blue/real orange two global pickup colors. And many other highlights.

  So, to sum up, what are the highlights of this global version of the Great Wall Gun that has attracted market attention?

  15 seconds new car analysis!

  1. The selling price has not increased, which improves the cost performance.

  2. Two new colors of "blue" and "true orange" are added.

  3. Maximum cargo hold of the same class of 1520mmx1520mmx538mm and maximum wheelbase of the same class of 3230mm

  4. Standard high-strength cage body, ACC and the latest intelligent driving control system, and 360 safety configuration without dead angle.

  5, 2 years of zero-interest financial policy, and basic services are free for life.

  

  

  In terms of appearance, the new car is equipped with a thicker chrome grille, a larger LOGO, and eagle-eye smart headlights, which have great visual impact. Two new color schemes, "blue" and "true orange", are also added.

  

  In terms of size, the largest cargo hold of the same class of 1520mmx1520mmx538mm and the largest wheelbase of the same class of 3230mm also make the global version of the pickup truck for the Great Wall cannon full of practicality as always.

  

  As for the interior, the soft interior covers the car everywhere, and the front and rear seats are heated, the rear elbow pillows, the cup holder, more than 100 noise reduction treatments and exclusive fragrance once again enhance the driving experience of the global version of the Great Wall Gun, making it one of the few pickup truck models with luxury configuration.

  

  In terms of configuration, all-liquid crystal virtual instrument, 9-inch central control touch screen, yacht-type bar and other scientific and technological applications are not absent. In addition, the global version of Great Wall Gun is also equipped with a new generation of intelligent network connection system. Users can realize air conditioning temperature adjustment, navigation settings, door and window opening, online payment and other applications through voice, and the intelligence of pickup trucks is greatly improved.

  

  Since the off-road attribute is emphasized, the safety of the global version of the Great Wall Gun has to be mentioned. In addition to "hard-core" safety equipment such as high-strength cage body, high-strength door anti-collision beam and double-layer anti-collision beam, the global version of Great Wall Gun is also equipped with the latest intelligent driving control system. For example, when driving at high speed, the ACC full-speed intelligent cruise system can not only follow the car, but also automatically slow down in corners; In the process of driving, the cooperation of the functions of parallel line assistance, lane keeping and lane departure warning can also make the safety 360 without dead ends.

  

  In terms of power, the global version of Great Wall Gun is equipped with a 2.0T gasoline/diesel engine, which is matched with ZF 8AT transmission. Among them, the former has a maximum power of 190 HP and a peak torque of 360 Nm; The latter has a maximum power of 163 HP and a peak torque of 400 Nm. With the help of TOD intelligent four-wheel drive, rear axle electronic differential system and multi-link rear suspension, the passability of the new car is also greatly improved.

  

  In the era of multi-purpose pickup truck 3.0, users’ demand for quality has been further stimulated. In this regard, Great Wall Gun announced that it has reached a strategic cooperation with China canoeing national team, and jointly launched a life adventure plan with Pathfinder brand to jointly build the "strongest ecological circle" of pickup truck culture.

  

  At present, for every two pickup trucks sold in China, one is the Great Wall! The market share of Great Wall pickup truck in domestic sales has reached 51%, and in 2018, when Great Wall pickup truck was just independent, its market share was only about 29%. It should be said that today’s Great Wall Gun has become a well-deserved "China No.1" pickup brand. In the global market, the Great Wall pickup truck has accumulated more than 1.9 million users.

  

  In addition, Great Wall Motor revealed that it will officially debut in China’s first full-size pickup truck at the Shanghai International Auto Show in April this year. The new car will be built by a tank platform with stronger power, higher reliability, intelligent off-road and other characteristics. The new car is worth the public’s expectation!

It may be the last time from 3999, Xiaomi 14 did not increase the price. What was upgraded?

With the release of Xiaomi 14, the price of 3999 yuan is still increasing without increasing the price. Lei Jun said that it may be the last time he saw 3999 yuan. This time, the upgrade of Xiaomi 14 is also very comprehensive, so what are its core upgrade highlights? Next, let’s take a look at it and see if it’s your dish.

In terms of performance, Snapdragon 8Gne3 can be said to have almost no rivals, and directly turned over Apple A17 Pro. At the same time, Xiaomi 14 also has LPDDR5X+UFS 4.0. With the cooling technology of annular cold pump, the game performance of Xiaomi 14 is also very strong. Among them, for 30 minutes, the temperature of the mobile phone was only about 43.2 degrees, but the frame rate was stable at 59.53 frames. I like to play games with a small screen mobile phone, and it’s really stable this time.

The screen size is still a 6.36-inch straight screen, which is comfortable to hold with one hand. Using Huaxing C8 screen, 1.5K resolution, 1-120HzLTPO variable refresh rate, local peak brightness of 1200nit, various eye protection and dimming blessing, the narrowest frame, 8.29mm thickness and 193g weight. This feel is really unmatched.

The camera is also fully upgraded, with a 32 million self-portrait neck brace in front and three 50-megapixel lenses in the rear. The main camera is 900, 1/1.31 inch of its own light and shadow hunter. Xiaomi 14 has dual OIS, Leica Summilux lens and F1.6 super aperture. Both telephoto and wide-angle are Samsung JN1 lenses, which support long-angle macro and floating telephoto. The performance does not lose the Pro version of Friends.

In other aspects, the battery capacity is 4610mAh, 90W wired fast charging, 50W wireless fast charging, 10W reverse wireless, and the surge P2 and surge G1 chips are all blessed. The detailed configuration is also a lot. Including infrared, NFC, IP68, customized version of X-axis motor, USB 3.2, WiFi 7, dual speakers and so on.

At the price, 8+256GB is still 3999, 12+256GB 4299, 16+512GB 4599, 16GB+1TB 4999. The price has not increased compared with the previous generation, but the storage has greatly improved compared with the previous generation. From the upgrade point of view, Xiaomi 14 is indeed very conscientious. Including storage, screen, performance, battery life, fast charge, face value, etc., it is indeed a 360-degree comprehensive upgrade. It is no wonder that the first pre-sale and some versions were snapped up. Did you buy Xiaomi 14?

2022 Chengdu Auto Show: The latest caravan of Great Wall Gun was unveiled.

  [car home New Car Launches] 2022 Chengdu Auto Show has officially opened, and (|) brand brought the latest "Camel RV" at the auto show. At the Tianjin Auto Show in 2021, the Great Wall once launched a free gun model. At that time, the price of the new car was 328,800-361,800 yuan. At that time, the supplier of the RV body was the audience. At the Chengdu Auto Show, we saw that the audience brought us another style.

Home of the car

Home of the car

  The structure of the car body of the two models is exactly the same, but the detailed design of the car body is obviously different. The new car adopts a brand-new mid-net design, which has a stronger visual impact. At the same time, the new car is upgraded to off-road tires, which can travel to further places. The body color is still matt.

Home of the car

Home of the car

  The car body structure, the door to get in and out of the car is changed to the rear of the car, the top of the cockpit is still the bed position of the car, and the rear part will be the kitchen and rest area. The window size of the car is average, and a trailer hook is provided at the rear of the car to meet the needs of users to carry trailers, and there is also a spare tire at the rear.

Home of the car

Home of the car

Home of the car

  Referring to the power of the previous free gun, the diesel version adopts GW4D20M 2.0T engine, with a maximum power of 163 HP and a peak torque of 400N·m;; The gasoline version adopts GW4C20B 2.0T engine, with the maximum power of 190 HP and the peak torque of 360N·m, which meets the national six emissions. It is matched with ZF 8AT automatic gearbox and equipped with Borg Warner TOD intelligent four-wheel drive. (Text/car home Wang Yin)

BYD’s monthly sales exceeded 10,000! Sales have climbed for four consecutive months.

A few days ago, BYD announced its November sales data. Among them, Han’s sales performance was outstanding, exceeding 10,000 vehicles, maintaining sales growth for four consecutive months. However, BYD’s cumulative sales in 11 months fell by 11.37% year-on-year.

Let’s be optimistic about the news first: Judging from the monthly sales performance in November, BYD’s new energy vehicles have achieved satisfactory results.

Data show that the sales volume of BYD’s new energy vehicles reached 26,690 in November, a year-on-year surge of 1.38 times. Affected by this, BYD’s overall sales in November reached 53,943 vehicles, up 30.63% year-on-year.

From the model, BYD Han sold 10,105 vehicles in November, achieving a four-month sales increase. Among them, Han EV sold 7,482 vehicles in November, an increase of 48% from October; Han DM sold 2,623 vehicles in November, up 5.3% from October.

Since its listing in July, BYD has sold 28,467 vehicles, including 19,766 EV and 8,701 DM.

However, judging from the annual sales performance, BYD’s overall sales performance is not satisfactory, with a cumulative sales volume of 370,650 vehicles, down 11.37% year-on-year; Among them, the sales volume of new energy vehicles was 160,848, a year-on-year decrease of 25.67%. On the contrary, fuel vehicles achieved positive growth, with 209,802 vehicles sold, up 3.96% year-on-year.

Bangpingdian

From the perspective of sales performance, we hope that BYD’s annual sales decline is affected by the epidemic at the beginning of the year and has not recovered.

Fortunately, with the release of production capacity, BYD Han’s sales volume continues to rise, and the monthly sales volume is close to half of BYD’s new energy. It can be seen that BYD Han has obviously been recognized by consumers in terms of product strength. As for whether BYD Han can "block" Tesla Model 3 next, let us wait and see.

Buying mobile phone software at half price cheats users into spending at high price.

  Sichuan Online News (Reporter Deng Tongtong) There is such a mobile phone software that claims to be able to shop at half price, including charging the phone bill. Do you believe such a good thing?

  Recently, Xiao Li, a college student in Chengdu, complained about an APP called "Half-price Group" through the online "Ask Politics Sichuan" platform in Sichuan. He spent two times "69 yuan" on the platform to recharge two different accounts. One account was "exchanged" for a phone card worth 100 yuan, and the other account was "exchanged" for a shopping fee in 69 yuan. Through the platform, the cash returned varied from 1 to 3 3 yuan every day, which 69 yuan could have received in full, but it was waiting for the process. — On August 7th, the half-price group suddenly revised the agreement, saying that "the shopping money below 100 yuan will no longer enjoy cashback", and Xiao Li felt cheated. (Original post link: http://ly.scol.com.cn/thread? tid=2757692)

  Two people buy at half price, only one person gets the goods. Netizen: The routine is too deep.

  Xiao Li became a half-price group user by accident. At school, she often asked a senior sister to help charge the phone bill. Every time she charged 100 yuan, it was always a few yuan cheaper, and the number of times she charged it was more and more familiar. "I thought that senior sister had any internal channels, but later I found out that she recharged her mobile phone through an APP called half-price group."

  Under the introduction of the senior sister, Xiao Li became a user of the half-price group. "The rule is this. In name, I used 69 yuan to charge 100 yuan’s phone bill, but in fact, I asked to use two accounts to recharge 69 yuan on the platform at the same time. One account got a phone bill recharge card worth 100, and the other account got a platform shopping fee from 69 yuan." Xiao Li explained that all the platform shopping money in 69 yuan will eventually be returned to users, ranging from 1 to 3 yuan every day, and the specific amount will be allocated according to the operating conditions of the platform on that day.

  In the face of such a huge profit, Xiao Li did not hesitate at all. "I thought that 69 yuan would eventually return it slowly anyway, and the amount was not much." She charged herself and her family for two months, spent hundreds of dollars, logged into the APP every day, activated her account and got cash back for shopping.

  The good times didn’t last long. In the second week of August, Xiao Li found that there was an abnormality when logging in the account to withdraw the shopping money. After several days of trying, it didn’t improve. After many twists and turns, it was discovered that the platform had released an announcement on the modification of the agreement on August 7: the shopping money below 100 yuan no longer enjoyed cash subsidies, but it did not affect consumption. "I immediately tried to communicate with the customer service, but the other party said that the shopping money can be used for shopping in the platform mall." Xiao Li immediately entered the mall to browse, only to find that there were only more than ten kinds of goods, and the prices were all higher than the market price, and some goods were even as expensive as 10 times. "A catty of rice in 20 yuan, five noodles for 88 yuan, is simply ‘ Rob money ’ 。”

  "When I became a half-price group user, the other party promised to return all the shopping money. If I don’t return it now, isn’t it equivalent to forcibly occupying the user’s funds?" Xiao Li is a little angry. "My platform shopping money is not much, only 200 yuan, but as a student, it is still very painful." She hopes to get justice through "asking politics in Sichuan".

  Consumers have invested more than 10,000 yuan and dare not complain. They are worried that the platform will close the money.

  Open the half-price group APP, advertising words "You want, we will pay half the money ‘ Purchase ’ "Suddenly appeared, become a member can enjoy half-price benefits? The answer may not be satisfactory, because in addition to Xiao Li, there are still many "traps".

  In May this year, Mr. Shi registered two accounts in the half-price group, and often recharged through one account, and the effect of recharging half-price was achieved by cashback of one account. On August 7, after the rules of the half-price group were changed, the accumulated 129 yuan in Mr. Shi’s two accounts could not be withdrawn.

  Netizen "Winona" revealed that some people around us have invested 10,000 yuan to buy a fuel card, which has been "set" at present. "The rules of APP describe the shopping money equivalent to RMB as a bonus, which is actually forcing consumers to buy at a high price in the name of half price." She believes that it is unreasonable and illegal to modify the rules without authorization. "The customer service said that the goods in the mall are new every Monday, Wednesday and Friday, but after observing for one week, it was found that the products in Tonggong were only two or three weeks old.

  Netizen "Mei Geni" said that there are not a few users who have invested 10,000 yuan, and some people have invested more than 300,000 yuan at most. She said that some users who have invested a lot of money don’t want to make a big deal out of it. They are worried that after the report, the company will have problems, and they will not get a penny back. "Because the user agreement stipulates that due to force majeure factors such as laws, regulations and policy changes in any country, the platform will be closed down, and the withdrawal will be terminated immediately. If the user’s shopping money is not withdrawn and consumed, we will not bear any legal responsibility."

Another new force to build a car owes wages and stops production.

Recently, we received feedback from employees of Henan Suda Electric Vehicle Technology Co., Ltd., and the problem of employees’ unpaid wages has not been effectively solved. It is understood that Henan Suda Electric Vehicle Technology Co., Ltd. has been in a state of suspension of production since the second half of 2020 due to its poor management and COVID-19 epidemic. Employees who have not left their jobs can’t go to work normally, and they can only receive basic living expenses, and sometimes even basic living expenses can’t be paid. Such a new power enterprise, which was the first batch to obtain "double qualifications" and was concerned by the governor, is now struggling and facing the situation of bankruptcy.

According to the feedback from employees at present, 12,000 yuan was paid in 2021, and 4,000 yuan has been paid so far in 22 years, and no penny has been paid for leaving the company. Sanmenxia currently has a minimum living guarantee of 1,900 yuan a month, so there is no minimum guarantee, and social security has never been paid since 2021.

In fact, since the problem of unpaid wages of Suda was exposed in 2020, there have been complaints from employees, but the problem has not been effectively solved. As early as the end of 2021, the local government replied: the management committee of the Development Zone has conducted many interviews with Henan Suda Electric Vehicle Technology Co., Ltd. on the issue of unpaid wages and unpaid social security fees, urging enterprises to implement their responsibilities, take measures to resolve hidden dangers of unpaid wages in time, do a good job in ideological counseling for employees and helping employees in difficulty, and properly handle the problem of unpaid wages. At the same time, the Development Zone Management Committee actively takes measures to help enterprises coordinate and solve production and operation difficulties and promote enterprises to gradually realize standardized management. In October, 2021, the municipal government and the administrative committee of the development zone set up a leading group for Sanmenxia City to promote the related work of Henan Suda Electric Vehicle Technology Co., Ltd. and a special class for the development zone to promote Henan Suda Electric Vehicle Technology Co., Ltd. to resume work and production, and arranged special personnel to carry out investment attraction and joint venture for Suda problem in order to solve Suda series of problems as soon as possible. In the next step, the development zone will urge enterprises to promote strategic restructuring as soon as possible, and at the same time actively do a good job in explaining and appeasing employees, strive for their understanding and support, properly handle contradictions, tide over difficulties with enterprises, and maintain social stability.

At present, the complaint platform of People’s Daily Online has also collected a large number of complaints about the unpaid wages of Henan Suda Company.

Some employees complained that "Henan Suda electric car does not pay wages, does not pay social security, and employees cannot be reimbursed for hospitalization. Since January 2021, social security has been broken off, and employees can’t be reimbursed for hospitalization. I called 12345 for feedback. The answer was that I suggested to the Development Zone Human Resources and Social Security Bureau about the salary and social security of Henan Suda electric employees, but there was no substantial progress in many feedbacks! Begging the government to come forward to solve this matter,. "

As early as 2021, employees of Henan Suda Electric Vehicle Technology Co., Ltd. (hereinafter referred to as Suda Company) broke the news. The company originally stipulated to pay the salary of last month on the 25th of each month, but by the end of November, the salary for three months from August to October was not paid, and the company leaders have not given a positive reply or any statement so far. It is worth mentioning that some employees were also "paid" 20,000 yuan for car booking, which was originally scheduled to be returned before June 30, and has not been returned so far, and there is no statement or reply. Now the employees of the company begin to ask for salaries in a large area and in various ways. By the 24th of this month, employees had gone to the chairman of the trade union to ask for salary. The chairman generally meant: If there is no money, it’s up to you. Send all the employees away. As of press time, the salary is still going on.

Suda, a key supporting enterprise in Henan province and city.

As the "No.1 Project" of Sanmenxia City’s transformation and upgrading, Henan Suda has been highly valued and strongly supported by Henan Province and Sanmenxia City. "The municipal party committee and municipal government provide nanny-like service to Suda Company, escort like a guard, rescue in time when the enterprise encounters setbacks, and devote themselves to it." The main leaders of Sanmenxia municipal government once lamented. However, for a long time, Henan Suda has made little noise in the new energy automobile industry. The last time it attracted public attention, it got "double qualifications". In 2019, the Ministry of Industry and Information Technology approved the qualification of Henan Suda to build a new pure electric passenger car manufacturer, which became the first car enterprise in Henan and the 11th in China to obtain "double qualification". However, Henan Suda, who holds the "double qualification" of building a car, is greeted with doubts one after another. Since its establishment in 2010, this enterprise has failed to independently produce a pure electric vehicle for more than five years, and has been accused of being "stiff but not dead", but it has been strongly supported by Sanmenxia City, Henan Province, where the enterprise is located.

According to public information, on February 10, 2011, the Implementation Opinions on the Development of Electric Vehicle Industry in Sanmenxia City (Provisional) stated that it is necessary to focus on cultivating Suda Technology to produce pure electric mini and mid-size cars, with an annual output of 100,000 vehicles by 2015. According to the plan, the Suda electric vehicle project has a total land area of 3,500 mu (826 mu in the first phase), with a total planned investment of 5 billion yuan, with an estimated annual output value of 35.6 billion yuan and a profit and tax of 7 billion yuan. After completion, a number of affiliated enterprises can be integrated to settle in, indirectly achieving an output value of more than 80 billion yuan, profits and taxes of more than 15 billion yuan, and attracting about 20,000 industrial workers. Obviously, this goal has not been achieved. According to authoritative media reports, in the case of shortage of land use indicators, the Sanmenxia municipal government gave priority to ensuring the land demand for the Suda electric vehicle project. The 705 mu of land required for the first phase of the project was approved by the provincial government in just 20 days; The approval procedures for environmental assessment, energy assessment and safety assessment of the project are all arranged by the government. In addition, Henan Suda also enjoys support policies in high-tech, environmental protection, new energy, energy conservation and comprehensive utilization. According to media reports, on March 13, 2020, Wang Guosheng, secretary of Henan Provincial Party Committee, went to Suda Company to investigate the situation of enterprise epidemic prevention and control, resumption of work and production, and scientific and technological innovation. Liu Nanchang, secretary of Sanmenxia Municipal Party Committee, accompanied the investigation.

During the investigation, Secretary Wang Guosheng spoke highly of Suda’s work in epidemic prevention and control, resumption of work and production, and scientific and technological innovation. Wang Guosheng said that Suda Company focused on the long-term and advanced layout, and while doing a good job in epidemic prevention and control, it promoted the resumption of production in a safe and orderly manner. It has many core technologies such as active control system, motor electronic control system and balanced discharge, which completely solved the safety problem of vehicles. At the same time,The sales of Suda pure electric cars at home and abroad have steadily advanced and achieved fruitful results..As the only pure electric passenger car enterprise in Henan Province, Suda Company will be strongly supported by the government and relevant departments.Therefore, I hope that in the future, Suda Company can accelerate its development, promote the development of related industries and make contributions to the economic development of Henan Province. Li Fuxing, the chairman of the company, said that in the future, Suda Company will take it as its responsibility to cultivate the industrial chain and supporting parts bases, push forward all the work of the company in a down-to-earth manner, and strive to build a 100 billion yuan industrial base for new energy vehicles.

A controversial enterprise

At present, there are only two products in official website of Henan Suda, namely the sedan SA01 and the small SUV SD01. After subsidy, the price is 130,000 yuan and 110,000 yuan. official website shows that the cruising range is 180-300 kilometers.

But there are only two products, and they are also accused of "sales fraud". In June 2020, there was media exposure, "Starting from Henan Suda: signing a fake sales contract with employees, a high-profile car company without a 4S shop."

According to the article, after visiting Sanmenxia City, the reporter found that even though every signing ceremony of Henan Suda was vigorous, there was no 4S shop in the local base camp, and the sales method was relatively hidden. Most citizens still knew little about Suda electric vehicles. Xiao Jing, an internal employee of Suda, told reporters that the company has been actively mobilizing employees to buy cars in order to "exchange" sales. If there is not enough money, it can even sign a contract with the company for "fake buying". The reporter found in the factory of Henan Suda that at present, only one phase of the factory has been built, and two more phases are under development planning. Only the sales exhibition hall is open to the public for the time being.

Although as the "No.1 Project" of Sanmenxia City’s transformation and upgrading, Henan Suda has been highly valued and strongly supported by Henan Province and Sanmenxia City. However, with the outbreak of the problem of unpaid wages in Henan Suda, more problems will be exposed. In the field of new energy vehicles, there are more and more such examples. Changjiang Automobile and Sailin Automobile are all falling down. Some insiders believe that the management ideas of government departments should be changed, and it is necessary to prevent enterprises from being tied too tightly to local governments. Once enterprises are stagnant, they will waste resources and funds, which will adversely affect the development of the industry.

Illegal e-commerce courier conspired to "cash on delivery 99 yuan" to defraud 12 million

  "Cash on delivery, 99 yuan." What will you do when the courier hands you such a package with the same mailing address, name and contact information? Recently, Nanjing police cracked a fraud case involving "cash on delivery" as a means to infringe citizens’ personal information and commit precise fraud, involving a total amount of 12 million yuan. The project police went to Zhengzhou, Henan Province to arrest 13 suspects involved in the case, including 6 employees of a courier company, which uncovered the "shady" crime caused by the "stubborn disease" of the delivery industry.

  The scam was exposed.

  Sixty-year-old aunt is "more real"

  Accidentally lift the veil of new criminal gangs

  In the early morning of July 23, Aunt Liu, a citizen of Nanjing, went into the Hanzhongmen Police Station of Gulou Public Security Bureau of Nanjing Public Security Bureau to call the police. It turned out that when she went shopping the day before, her daughter signed a cash on delivery express in 99 yuan for her. "My daughter’s name, address and telephone number are all right, and she paid the money without thinking. But I didn’t buy online at all recently. When I opened it, it was a solar wall lamp, which was worth more than ten yuan at most. Isn’t it obvious that I was cheated? " Aunt Liu said that she called the sender’s phone number on the courier, but no one answered, let alone return the goods for a refund.

  "Originally, my family advised me to forget it. If it was less than one hundred dollars, I would admit that I was unlucky, but I thought about it all night and I couldn’t figure it out. How did these people know my personal information? Are there many people like me who have been cheated? There are not many 99 yuan, and if it is gone, it will be gone. But if everyone does not call the police, these scammers will let them go unpunished? " Aunt Liu said. And her doubts and trueness have touched the keen nerves of the police, such as accurate personal information, small-scale widespread casting of nets, and goods with unequal value … … The characterization labels of these cyber crimes all point to new fraud crimes.

  After receiving the report, the Party Committee of Nanjing Public Security Bureau attached great importance to it, and the Netan detachment of Nanjing Public Security Bureau dispatched elite police force to form a task force with Gulou Public Security Bureau to carry out case detection. The project police went to Zhengzhou, Henan Province to investigate according to the mailing address on the courier.

  The case is amazing.

  The courier and the illegal e-commerce are in cahoots.

  Actually moved the company computer to steal citizen information.

  After investigation, Zheng, a legal person of a technology company in Zhengzhou, has been engaged in e-commerce promotion business in the early years, and promoted the company’s products through the "push and implantation" of well-known network platforms. Zheng worked hard to get a job, and when chatting with the courier salesmen Liu and Wei, who had been familiar with long-term cooperation, he suddenly got the idea.

  "Your courier company internal system can not find all customer information? You provide it to me, and I will spread the net widely in the way of cash on delivery, so that I can save the cost of advertising operation, and your delivery volume will go up, so that performance pay will come. I will give you 5 points at the end of the year. " Zheng and the courier discussed this.

  The two sides hit it off, and driven by the "win-win" interests, a clear division of labor was formed, with Zheng supplying the goods, Liu stealing the data, Wei doing the after-sales work and Luo doing the coolie, each showing its strengths and being meticulous.

  Because Liu is the leader of the express delivery salesman and is familiar with the operating system of the company, he has obtained the keys of three sales managers and stole customer data with their connivance. Wei is timid and shy, so it is appropriate for him to be responsible for the after-sales appeasement work. Luo is mainly responsible for picking up goods from Zheng’s company warehouse. What shocked the police was that two-thirds of the steps in the whole crime process were actually completed by the courier company.

  Because it is getting easier and easier, and because of the huge delivery volume, the average daily delivery is 5000 pieces. Finally, the three people were so mad that Liu moved the computer with the company’s internal system to Zheng’s office and directly imported the accounting delivery name. The generated express bill was like running water, hundreds of meters long. Luo directly drove the truck of the courier company to Zheng’s warehouse, and hired more than a dozen laborers to find goods, pack, pack, label and scan together. Wei has a precise grasp of the victim’s psychology, and one in a thousand people can meet a more difficult one. In case the victim goes to the local express delivery point to make a statement, he will privately negotiate with the dispatcher for a refund.

  Police reveal secrets

  The suspect is very precise about the victim’s psychology

  A courier bill hides the triple smoke screen.

  According to the police investigating the case, in June this year, Liu, Wei and Luo only received performance pay linked to the number of shipments from their courier companies, with a per capita salary exceeding 50,000 yuan. Then, Liu steals user data. Does the company have no supervision and early warning? The police said that this is because there is a "stubborn disease" in the delivery industry.

  It turns out that the courier company has many branches all over the country, and each branch has competition in the volume of delivery. In order to get the first place in the performance ranking, all branches will try their best, which is why all three department managers of Liu are conniving at his criminal behavior. In this regard, the relevant person in charge of the courier company said: "This kind of industry ills is not the existence of our courier company, but we will vigorously cooperate with the police to find out the ghost of the company and conduct self-examination. In the future, we will take the warning and force the supervision and rectification to prevent the delivery industry from falling into the hardest hit area of cybercrime. "

  "The criminal suspect has grasped the victim’s psychology very accurately. This courier list hides the triple eye-catching method and accurately pokes the difficulty and pain of the current consumer rights protection." Jiang Guangdong, the captain of the Netan detachment of Nanjing Public Security Bureau in Gulou District, said that this kind of fraud also has its own "model".

  The first heavy cover-up method of Smith — — Shipper’s name: fictional, this need not be explained too much, because as a victim, it is impossible to verify the authenticity of a name. But "dare to leave your name" itself is a powerful psychological hint of authenticity.

  The second cover-up — — Shipper’s phone: This number looks like a fixed phone, but it is actually a mobile communication terminal, which is the "PHS" that was widely used in earlier years and has now been eliminated. When the victim made this call, there was basically no answer. The reason why the suspect doesn’t simply fill in an empty number is to confuse the victim, because if it is empty, the victim will immediately react and be cheated and choose to call the police. Only when the same number is dialed repeatedly throughout the day will the phone be connected. In order to appease the victim’s emotions and prevent him from waking up and calling the police, the suspect will use various excuses such as sending the wrong goods and returning the goods to delay the war.

  The third diversion — — Shipping address: According to the investigation of the task force, the address left by the suspect on the express bill is a science and technology industrial park, and the real suspect’s address is actually next door to this industrial park. The reason for this setting is as follows: first, the industrial park itself is confusing and looks like the location of a formal company; Second, it is hidden in the city. This industrial park covers an area of more than ten acres, and the address does not indicate which area, so it is impossible to deliver it if you only follow this address.

  However, "no matter how cunning the fox is, it can’t escape the hunter’s eyes." This criminal gang was finally detected by the Nanjing police and 13 suspects were arrested. (Yangzi Evening News/Yangyan reporter Mei Jianming correspondent Ning Gongxuan)