How does WeChat activate China Unionpay Quick Pass function? Introduction of WeChat applet supporting China Unionpay Quick Pass payment method

　　　　　　Ordinary users of China Unionpay Quick Pass function can’t open it on WeChat. Only when merchants open China Unionpay Quick Pass payment, users can use China Unionpay Quick Pass to pay in small programs.

　　　　　　Merchant opening steps:

　　　　　　Log in to the backstage of WeChat payment merchants-> Product Center-> Development Configuration page, find "Payment Method Configuration" at the bottom, and click "Open". There is no need for any additional configuration. After opening, as long as the user’s mobile phone is equipped with China Unionpay Quick Pass app, they can choose to pay in China Unionpay Quick Pass when paying for the applet.

　　　　　　Steps for users to pay with China Unionpay Quick Pass:

　　　　　　1. When the merchant opens China Unionpay Quick Pass, when users make payment in the applet, two signs, WeChat Pay and China Unionpay Quick Pass, will be displayed below, and click China Unionpay Quick Pass.

　　　　　　2. Click Allow according to the page prompts, and then you can jump to China Unionpay Quick Pass app.

　　　　　　3. Finally, click to confirm the amount and click Pay Now.

On January 8, 2023, the 20th Guangzhou International Automobile Exhibition (hereinafter referred to as "Guangzhou Automobile Exhibition") held in New Year’s Eve came to a successful conclusion. At the same time, the official said that the 21st Guangzhou International Automobile Exhibition will open from November 17th to 26th, 2023.

According to the official, this year’s Guangzhou Auto Show opened the newly-built D-Zone Pavilion of the Canton Fair for the first time, with an exhibition scale of 220,000 square meters, attracting a total of 383,000 visitors.

On the first day of media day, we welcomed the launch, listing and pre-sale of more than 60 heavy new cars. In this summary article, you will see: Great Wall Shanhai Gun, Wei Brand Blue Mountain, Chang An Yi Da, Hongqi H6, brand new Crown SportCross, brand new Crown Sedan, brand new BMW M2, brand new Civic TYPE R and brand new Mazda CX-50, etc. The 20th Guangzhou Auto Show can be said to be a successful conclusion for the automobile circle in 2022.

Ford L was released at Shanghai Auto Show in April, 2023. Its body length, width, height and wheelbase are 5000 mm, 1961 mm, 1773 mm and 2950mm, respectively, which makes it have obvious space advantages in medium-sized SUVs. The price range from low-priced fuel version to high-priced hybrid is 229,800 to 309,800 yuan, which can be said to cover the price range of mainstream compact, medium-sized and medium-sized SUVs, regardless of product strength.

However, from listing to the end of 2023, the total sales volume was 25,502 vehicles, with an average monthly sales volume of 2,125 vehicles, ranking 197th among the national passenger car sales. After combining the strength of its products, it is really a pity that such a flat sales performance has been achieved. You know, the average monthly sales volume of the same power split hybrid technology reached 6120 units.

Of course, the performance of sales volume is related to many factors, first of all, the product strength. Ford Sharp L adopts the latest design language of Ford family, and the spoke lattice air intake grille with dynamic LED headlights gives this SUV a strong visual impact, which is extremely aggressive compared with the old one.

The side of the car body is slender, and the uplift design of the C-pillar position adds a sense of movement. In terms of interior design, it is equipped with a 12.3-inch full LCD instrument panel and a 27-inch touch screen, which is reasonable in layout and convenient to operate. It not only provides rich information for passengers, but also enhances the sense of interactive experience. In terms of spatial layout, Ford Sharp L has realized the design of 2+2+3 with a wheelbase of 2950mm, and the maximum legroom in the second row is 1,190 mm. It is equipped with seat ventilation, heating, independent temperature zone control, wireless charging, etc. It can switch the near-zero gravity mode with one button, the backrest angle can be adjusted backward to 41 degrees, and the included angle between the backrest and the seat cushion can reach 105 degrees, making it comfortable to ride. The narrowest distance of the central passage is 200mm, and the armrest can easily enter and exit the third row after being folded, so that family users can experience comfort and convenience whether they travel daily or long distances.

However, the design is a matter of opinion, mainly in the actual experience, most users feedback that the hidden door handle can not be extended after unlocking, and it can be replaced or repaired through warranty. The display effect of the central control screen is average, and there will be problems such as crash, slow response, occasional blue screen, and unable to change the driving mode during use, which can be solved by restarting and upgrading the car. In the process of driving, the driver’s and passenger’s doors will produce abnormal noise when traveling in bumpy road conditions. The main reason is that the lock collides with the door lock, which can be solved by wrapping tape. There are also small problems such as abnormal sound of skylight and stuck ignition switch, which are within the scope of recall. In addition, the Ford Sharp L platform has been downgraded from the previous generation CD4 to the same C2 platform as Ford. Ford and Lincoln also use this platform. The material of the chassis suspension swing arm has been replaced by the seemingly cheap iron, which invisibly reduces the brand power and affects the choice of Ford potential users to a greater or lesser extent.

To sum up, even if Ford Sharp L’s product strength is excellent, there is still much room for improvement in terms of quality reliability and brand strength. At the same time, in the impression that American cars bring to consumers, oil consumption seems to be an indelible stain. The Ford Sharp L 2.0T EcoBoost E- hybrid will make you change your view of American cars.

Ford Sharp L 2.0T EcoBoost E- hybrid is equipped with a hybrid system with power split configuration. When it comes to this technology, most people will take the lead in thinking of Toyota’s THS hybrid system. Yes, the hybrid configuration of Ford and Toyota is completely the same. However, Ford did not copy or buy Toyota’s hybrid technology. Strictly speaking, it is more appropriate to call it technology sharing.

Power split configuration was not first put forward by Toyota or Ford, but a design concept put forward by TRW Company in 1960s. When the development of new energy technology was officially valued by the main engine factory, Toyota and Ford began to develop this hybrid configuration at almost the same time. Among them, Toyota has made breakthroughs in control system and energy management, while Ford has put more energy into hybrid configuration and machinery manufacturing. In 2004, Ford signed an authorization agreement with Toyota. The details are that Ford replaced 20 patents related to hybrid technology with diesel engine technology. This behavior was misunderstood by many people. It was considered that Ford’s hybrid technology originated from Toyota, which is actually a kind of patent cross-authorization, because in the configuration of power split hybrid system, neither Toyota nor Ford can avoid each other’s patents. After evading the legal issues, Ford began to make great efforts in the power split hybrid configuration, including control strategies and algorithms, and applied for more than 100 patents.

So today, 20 years later, we saw this latest hybrid system on Ford Sharp L. The 2.0T EcoBoost E- hybrid consists of the fifth generation 2.0T EcoBoost single-turbo twin-turbo supercharged dual-injection engine and the eCVT transmission with dual motors. The maximum power is 202kW/5500rpm and the maximum torque is 405Nm/3000~4000rpm. Compared with Toyota 2.5THS, the power performance is better, and compared with Toyota 2.4T hybrid system, the cost control is better.

In the hybrid system, the engine uses a 350-bar dual-injection fuel system, which can automatically select the intake manifold or in-cylinder direct injection fuel injection mode according to the working conditions, which can better balance the low fuel consumption at uniform speed and the power performance at high power demand. At the same time, it also adopts hydraulic control OCV, VCT, valve mechanism and EGR exhaust gas circulation system. The eCVT transmission, code-named HF55, adopts a set of Power-Split structure in which the engine and generator are coupled by planetary gear sets, and the motor, motor controller, vehicle controller and gearbox are highly integrated. It has the characteristics of compact structure, energy saving, high efficiency, smoothness and sensitivity, and the maximum output torque can reach 5000Nm. Among them, both generator and motor are developed by Ford, and flat wire winding technology is adopted. The slot full rate exceeds 60% and the efficiency reaches 96.2%. With the oil cooling technology of frequency conversion electronic oil pump, the motor speed can reach 17000rpm, the driving motor output power is 140kW, and the torque reaches 320Nm.

The new low-nickel NCM111 ternary lithium water-cooled battery pack comes from BYD. It adopts an integrated high-efficiency water-cooled system, which not only has excellent heat dissipation performance, low risk of thermal diffusion, but also has a long cycle life. It has passed many rigorous tests exceeding national standards such as overcharge, acupuncture, seawater immersion, salt spray, drop, high and low temperature impact and cycle life, and can maintain the normal and safe operation of the battery under extreme conditions. Even at low temperature in winter, the battery pack of the hybrid system can cooperate with the new generation of EcoBoost twin-vortex turbocharged engine to realize continuous and stable automatic charging and discharging.

During the driving process, the whole system can be freely switched between pure electric drive, hybrid drive and electric assist. When various modes are switched, the NVH of the whole vehicle will be very natural. Even when the engine is started or accelerated with a large throttle, the driver and passenger will not feel the sharp attack of noise and vibration after the engine is started, but can only vaguely hear the noise with coarse particles when the engine is running.

The dynamic performance of the whole vehicle takes into account responsiveness and smoothness. However, in the power connection at the moment when the engine is involved, there will be a rush feeling dragged by the power. Although it is small, the ride comfort needs to be improved compared with Toyota’s hybrid system.

It is worth mentioning that the vehicle control system accurately calculates the optimal efficiency of the engine and motor, and automatically matches the optimal driving mode according to the actual working conditions, so that the hybrid power system always runs in the optimal efficiency interval. Considering the total mileage of 800 kilometers in urban areas, highways and suburban mountain roads, the average fuel consumption reaches 8.4L/100km, of which 188.5km is for pure electric driving. For a hybrid SUV, this fuel consumption may not be the most fuel-efficient, but considering its power performance and 5 meters.

Except for the engine, the most obvious difference between Ford’s power splitting technology and Toyota THS is the four-wheel drive system. In Toyota THS, the E-Four four-wheel drive system is adopted, that is, the engine and the driving motor drive the front wheels, and the driving motor located at the rear axle drives the rear wheels. There is no transmission shaft between the front and rear axles, and the power distribution is automatically controlled by the electronic control system. In the Ford Sharp L 2.0T EcoBoost E- hybrid, there is a transmission shaft leading from the output end of the hybrid system to the rear axle, realizing a real four-wheel drive system, which not only can bear higher load and bring better four-wheel drive performance, but also takes into account fuel economy.

Today, with the wave of electrification and intelligence sweeping the world, the status of traditional luxury cars seems to be challenged as never before. However, at the Beijing Auto Show in 2024, Hongqi Automobile showed the world the unique understanding of high-end luxury by a brand-new large car-Guoya series products. Its direct competitors were Rolls-Royce Phantom and Bentley Flying.

Hongqi Guoya, with its excellent quality and extraordinary temperament, declared the strong rise of China car enterprises in the luxury car market. This new car is designed with rounded lines, creating a stretch and elegant visual effect. Its body size has reached the level of a large car, with the length, width and height of 5353mmx1998mmx1511mm and the wheelbase of 3260mm, providing passengers with spacious and comfortable seating space.

In the front face, Hongqi Guoya uses a lot of chrome-plated materials, and creates a strong visual impact through the design of large-size straight waterfall grille. The hollowed-out design of the front enclosure is unique, and the wing-like patterns at the fog lights on both sides of the bumper embellish the atmosphere of the whole vehicle just right. The headlight group adopts a rounded external contour, and the lamp holder with lens inside is in a vertical layout, emitting a unique light that shines like a diamond.

On the side of the car body, Hongqi Guoya looks elegant, calm and smooth. The chrome-plated decorative strip above the threshold rises slightly and extends to the rear of the car, which harmoniously coexists with the traditional door handle design. The exquisite grid texture on the door handle highlights the exquisiteness and luxury of the new car. In addition, the new car also uses 20-inch aluminum alloy wheels with dense stripes, which match the PremiumContact C high-end tires, further enhancing the business atmosphere of the whole car.

In terms of interior, Hongqi Guoya adopts a symmetrical layout, and the design contains elegant and upright Chinese beauty. The use of a large number of soft packages has greatly enhanced the sense of luxury in the cockpit. The pointer clock at the top of the center console is exquisitely made, and the words "1958" are printed on it, which symbolizes the historical moment of successful trial production of the first high-class car in New China. The new car also adopts the design of the chest block, and integrates a variety of function buttons in the central control armrest part, which is convenient and practical to operate.

In terms of power, Hongqi Guoya is expected to push the 3.0T hybrid system with the maximum engine power of 290kW. The high-end model will provide a 4.0T hybrid system with an engine power of up to 360kW. This power configuration is enough to make Hongqi Guoya stand out in the luxury car market.

　　On November 27th, the first converter transformer with domestic on-load tap changer independently developed by China was installed in the key project of West-to-East Power Transmission in Conghua, Guangzhou — — Xiluodu DC project has been successfully put into operation from West Converter Station.

The picture shows the Xiluodu DC project from the west converter station. (Photo courtesy of the interviewee)

　　"The on-load tap-changer of converter transformer has achieved a technical breakthrough from scratch and realized the complete localization of industrial chains such as components, which indicates that China has broken through the constraints of this key core technology of high-end power equipment." Feng Wei, deputy general manager of Biotechnology Department of China Southern Power Grid EHV Company, said.

　　China’s eastern and western parts span thousands of kilometers, and the power transmission from west to east needs a long-distance, large-capacity and high-voltage DC project for power transmission. The converter transformer, which weighs more than 300 tons, is used in both the power transmission end and the power reception end of the project. The on-load tap-changer of converter transformer is like an automatic gearbox of a car, and it is used to adjust the voltage, load and current.

　　On-load tap changer is a highly complex and precise equipment. According to Deng Jun, a senior technical expert of China Southern Power Grid EHV Company, the on-load tap changer of converter transformer has more than 1,000 parts, and the switching times are very frequent, reaching more than 6,000 times a year. One switching includes nine processes, each of which involves the precise coordination of more than 400 parts, and the timing coordination of each process is millisecond, and the multi-field coupling of electricity, heat and force is involved in the action process.

The picture shows the installation site of on-load tap changer of converter transformer. (Photo courtesy of the interviewee)

　　Due to the extremely high reliability requirements and difficult manufacturing, this technology has always been in the hands of a few foreign manufacturers, and equipment maintenance is also limited. In case of failure, only imported products of the same model can be replaced, and the order cycle takes 3 to 4 months, which brings challenges to the safety of power operation.

　　Liu Xiangqiang, deputy general manager of China Southern Power Grid EHV Company, told the reporter that after more than two years of hard work, the research team jointly established by China Southern Power Grid EHV Company and upstream and downstream enterprises in the industrial chain has successfully developed a large-capacity converter transformer on-load tap changer with rated capacity of 6000kVA, maximum voltage of 6,000 V and maximum rated current of 1,300 A, and realized the domestic manufacturing of the whole chain of "raw materials-components-complete machine".

The picture shows the installation site of on-load tap changer of converter transformer. (Photo courtesy of the interviewee)

　　The successful operation of this product will not only help to upgrade the industrial chain of high-end electrical equipment in China, but also save costs for engineering construction. According to Liu Xiangqiang, only from the equipment cost estimation, the on-load tap-changer of domestic converter transformer can save nearly 40 million yuan for a new UHVDC transmission project. (Reporter Wu Tao)

Today, Chery Automobile officially announced that the Chery Fengyun T9 Long Life Edition was officially launched. Compared with the models on sale, the biggest change of the new car lies in the upgrade of the transmission system, from single-gear DHT to three-gear DHT, and at the same time, the pure electric cruising range is increased to 210km, providing consumers with more choices.

In appearance, the Chery Fengyun T9 Long Life Edition continues the overall design of the models on sale, and the closed front face highlights the new energy features while retaining the Chery family elements. The new car comes standard with LED headlights with automatic headlights, and some models are also equipped with adaptive far and near lights. The side design is simple, and the hidden door handle is integrated. The body size is 4795/1930/1738mm and the wheelbase is 2770 mm. The design of the rear is layered, and Fengyun English Logo is located under the penetrating taillights.

For the interior, the Chery Fengyun T9 Long Life Edition comes standard with a 15.6-inch central control screen, which integrates multiple functions, while retaining the driving mode switch knob and shortcut keys. In terms of power, the new car is equipped with a combination of 1.5T and 3-speed DHT. The maximum power of the engine is 115kW and the maximum torque is 220N·m； The comprehensive power of the system is 265kW and the comprehensive torque is 530 N m.. It is estimated that the 34.46kWh Ferrous lithium phosphate will have a pure electric cruising range of 210 kilometers.

A few days ago, pickup truck city learned from the Great Wall official that,China’s first 6X6 super off-road platform built by Great Wall Motor will be the world’s first show at the Shanghai Auto Show, which opened on April 18th this year, creating a brand-new category and leading China’s hard-core off-road to the next level. The first application of the Great Wall 6X6 super off-road platform technology will be the Great Wall Gun.The first "3-axis, 6-drive and 5-lock" in China has achieved the super off-road capability in all scenes and all terrain, and can realize the infinite expansion of the whole ecology.

At present, more specific information about the 6×6 version of the Great Wall Gun is unknown for the time being. According to the product planning information previously exposed, the new car willContinuing the chassis structure of front independent suspension with front double wishbone and rear multi-link integral bridge for the ordinary version of Great Wall Gun, the newly developed through middle bridge can bring longer suspension stroke and enhance off-road performance. Six-wheel-drive pickup truck has a longer vehicle size due to the addition of a rear axle, and the container can carry larger items, but it also tests the vehicle length control ability. If it exceeds 6 meters, it needs to hang a yellow motor vehicle number plate.

In terms of power, according to the common reference of six-wheel drive pickup trucks around the world, guessThe 6×6 version of Great Wall Gun is likely to adopt the top 3.0T V6+9AT combination of Great Wall Motor, with a maximum power of 260kW and a peak torque of 500N·m, providing consumers with stronger performance guarantee.

Six-wheel drive off-road pickup trucks are ceiling-level products all over the world, among which the most famous ones are modified models such as Mercedes-Benz G63 AMG 6×6, Hennessy Ram TRX Mammoth and Hennessy Veloci Raptor, which have conquered countless off-road enthusiasts with the off the charts performance of three-axle six-wheel drive+thousand horsepower+five locks.

Compared with the traditional four-wheel drive chassis, the chassis of six-wheel drive pickup truck has stronger stability and bearing capacity due to the design of double rear axles. Compared with heavy and medium-sized trucks, it has the characteristics of flexibility and maneuverability, which is more advantageous for RV modification, cross-country crossing and special vehicle building, and is very suitable for product development in the civilian market. Therefore, the appearance of the 6×6 version of Great Wall Gun will be a historic progress of domestic pickup trucks.

On March 16th, BYD held the Super Press Conference of Han and Tang Flagships today, and officially released the 2023 Han EV Champion Edition.The price range is 209,800-299,800 yuan..

IT House with 2023 BYD Han EV Champion Edition Price of each model:

In terms of design, the 2023 Chinese EV Champion Edition adopts the "Dragon Face" design language, with Chinese tail lights.Add Glacier Blue Car Paint Color Matching.

In terms of configuration, the new car is equipped with a 15.6-inch adaptive rotating Pad, which supports NFC car keys, wireless charging of mobile phones, high-efficiency heat pump air conditioning in a wide temperature range, and independent partition atmosphere lights.

In terms of power, the 2023 Chinese EV Champion EditionSingle motor and dual motor versions are available.. Among them, the single motor model has three power versions:

In addition, dual-motor modelsThe maximum power of the system is 380 kW and the combined torque is 700 Nm.The maximum power of the front motor is 180 kW and the peak torque is 350 Nm, and the maximum power of the rear motor is 200 kW and the peak torque is 350 Nm.CLTC cruising range 610km.

Chassis, Han EV Champion EditionEquipped with front McPherson+rear multi-link independent suspensionFSD variable damping suspension is standard for front-wheel drive vehicles, DiSus-C intelligent electronically controlled active suspension is equipped for four-wheel drive vehicles, and the suspension arm and steering knuckle are made of materials.Change from iron material to aluminum alloy material.

Suzhou, China, Palo Alto, California, USA May 20, 2021/PRNewswire/-Genxi Biotechnology Group (NASDAQ: GRCL；; Genxi Bio, a global clinical biopharmaceutical company dedicated to developing efficient and economical cell therapy for cancer treatment, announced today that it will publish the latest clinical research results of a multi-center, first-time human trial on GC012F in the treatment of relapsed/refractory multiple myeloma during the annual meeting of American Society of Clinical Oncology (ASCO) in 2021 and the conference of European Hematology Association (EHA) in 2021.

GC012F is a BCMA/CD19 dual-target autologous CAR-T cell therapy developed based on the patented technology platform of Genxi Bio-FasTCAR, which has the advantage of "production can be completed the next day". At present, the candidate product is being evaluated in a phase I clinical trial initiated by researchers.

• By January 12, 2021, 19 patients with multiple myeloma were enrolled in the three dose groups of this study, of which the highest dose level was 3×10.^fiveCells/kg body weight, all the above patients meet the criteria of recurrence/refractory after multiple rounds of treatment. Subsequent patients (after the release of data at the ASH annual meeting in 2020) received the highest dose level of treatment.
• The early objective remission rate (ORR) was as high as 94.7%(18/19), and all the responses showed that excellent partial remission (VGPR) and even complete remission (SCR) were obtained. The data of all dose groups showed a rapid, in-depth and lasting therapeutic effect.
• All patients (n=9) who received treatment in the highest dose group achieved negative minimal residual lesions-complete remission (MRD- sCR) in a strict sense.
• Of the 19 patients, 18 (94.7%) belonged to the high-risk patients defined in mSMART 3.0 guidelines, and the median number of previous treatment lines was 5.
• 94.7%(18/19) patients have been exposed to PI, IMiD and at least the third treatment scheme, including anti-CD38 targeted therapy.
• The safety of GC012F is consistent with the previous observation results, and the main symptom is low-grade cytokine release syndrome (CRS)(84% patients are grade 1/2; 11% (n=2) patients were grade 3), and there was no grade 4 or 5 CRS；. No immune effector cell-related neurotoxicity (ICANS) was observed in 19 patients. Adverse events (TEAEs) occurred during treatment were mainly manifested as decrease of blood cell count and increase of AST. All TEAEs were relieved after standard treatment.
• The study will continue to evaluate the effectiveness and safety of GC012F in the treatment of patients.

"I am glad to see the mutual evidence between the follow-up of the initial patients and the treatment effect of the subsequent patients, which not only confirms the research results announced at the annual meeting of ASH last year, but also further clarifies the excellent safety and effectiveness of GC012F dual-targeted autologous CAR-T cell therapy, including for high-risk patients."Chief Medical Officer of Genxi BiologydoctorIt said: "High-risk patients are usually extremely difficult to treat, but all patients in the highest dose group in this study have reached the MRD negative sCR state and maintained a deep response for six months or even longer after receiving GC012F infusion. The above exciting research data bring brand-new hope to high-risk patients (including those who do not respond to the standard treatment plan). Next, we plan to promote this research on a global scale, including promoting it as a more preferred treatment option. I look forward to sharing more developments with you in the near future. "

GC012FClinical research initiated by researchers (IIT) Co-principal researcher, Professor Du Fu of shanghai changzheng hospital."Multiple myeloma (MM) is a malignant blood tumor that is extremely difficult to treat. There are about 750,000 patients with multiple myeloma worldwide.^[1]There are about 160,000 new patients every year.^[2]And it is on the rise year by year. Among them, high-risk patients account for 20%-30%.^[3]The prognosis is usually poor, accompanied by higher risk of early recurrence, shorter progression-free survival and overall survival. This time, we are pleased to see that the BCMA/CD19 dual-target autologous CAR-T cell therapy GC012F of Genxi Bio has shown excellent effectiveness and safety for the long-term follow-up results of patients with relapsed/refractory multiple myeloma. And thanks to the advantages of FasTCAR platform, the waiting time of clinical treatment has been significantly shortened, and the hope of life has been ignited for more patients. "

GC012FClinical research initiated by researchers (IIT) Co-principal researcher, Professor Fu Weijun of shanghai changzheng hospital.Said: "I am very happy to see that after we announced the first human trial data of GC012F in the form of oral report at the ASH meeting last year, this research has made positive progress again, and the previous results have been further verified; This also allows us to see the good application prospects of Ganxi Bio-FasTCAR platform and Dual CAR technology. With the deepening of research, the clinical benefits of this innovative BCMA/CD19 dual-targeted autologous CAR-T cell therapy for patients with multiple myeloma, especially high-risk patients, are constantly emerging. It is expected that this research will continue to achieve more results and strive to meet the urgent treatment needs of patients with recurrent/refractory multiple myeloma as soon as possible. "

Details of the electronic poster are as follows:

2021American Society of Clinical Oncology (ASCO) annual meeting

abstract8014：Long-term follow-up results of the first multicenter human trial of BCMA/CD19 dual-target CAR-T cell therapy GC012F for patients with relapsed or refractory multiple myeloma based on FasTCAR platform.

Poster release date:June 4, 2021

2021European hematology association (EHA2021) conference

abstractEP962：Long-term follow-up results of the first multicenter human trial of BCMA/CD19 dual-target CAR-T cell therapy GC012F for patients with relapsed or refractory multiple myeloma based on FasTCAR platform.

Poster release date:June 11th, 2021

About multiple myeloma

Multiple myeloma (MM) is the third most common malignant hematological tumor in the United States. Its tumor cells originated from bone marrow plasma cells, an immune cell responsible for secreting anti-infective antibodies. About 160,000 patients worldwide are diagnosed with multiple myeloma every year; In 2020, the United States is expected to have more than 32,000 confirmed patients. In recent years, although many progress has been made in the treatment of multiple myeloma, the clinical treatment effect is still unsatisfactory. International Myeloma Working Group (IMWG) and the consensus guidelines of Mayo ST Rating for Myeloma and Risk-Adapted Therapy (MSMART) classify patients with specific cytogenetic abnormalities or other abnormalities as high-risk patients, and this group accounts for 20-30% of all patients with multiple myeloma. High-risk patients with high risk of early recurrence, progression-free survival and short overall survival are considered as the most difficult patients with multiple myeloma, and usually have poor prognosis.

aboutGC012F

GC012F is a candidate product for dual-target autologous CAR-T therapy based on FasTCAR platform. At present, the candidate product is evaluating its safety and effectiveness in the treatment of multiple myeloma in a multi-center and phase I clinical trial initiated by researchers, covering many research centers in China. GC012F brings rapid, in-depth and lasting therapeutic effects to patients with multiple myeloma by simultaneously targeting the malignant plasma cell site expressing BCMA and the early progenitor cell site expressing CD19.　

aboutFasTCAR

FasTCAR is a technology platform with intellectual property rights of Genxi Bio, aiming at developing high-quality autologous CAR-T cell therapy. Preclinical studies show that the phenotype of CAR-T cells produced by FasTCAR technology platform is younger, the degree of depletion is lower, and the amplification ability, persistence, bone marrow migration ability and tumor cell clearance activity are enhanced. With the advantage of "completing production the next day", FasTCAR platform technology can greatly improve cell production efficiency, thus significantly reducing production costs and enabling cell therapy to benefit more cancer patients.

About genxi creatures

Genxi Biotechnology Group (Genxi Bio for short) is a global clinical biopharmaceutical company dedicated to the discovery and development of breakthrough cell therapy. Using its pioneering FasTCAR and TruUCAR technology platforms, Genxi Bio is developing a number of rich clinical cancer treatment product pipelines, both autologous and allogeneic. These products are expected to overcome the persistent major industry challenges of traditional CAR-T therapy, including long production time, poor production quality, high treatment cost and lack of effective treatment for solid tumors. To learn more about Genxi Bio, please visit www.gracellbio.com/ Concern LinkedIn account @GracellBio.

Warning statement about forward-looking statements

The statement in the press release about future expectations, plans, prospects and other non-historical facts may contain a "forward-looking statement" as defined in the Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements related to the expected transaction and completion time of this offering. These statements may, but do not necessarily, contain the following words and corresponding negative forms or similar words: purpose, expectation, belief, estimation, prediction, plan, possibility, prospect, plan, potential, conjecture, formulation, seeking, possibility, should and will. Due to various important factors, the actual results may be significantly different from the forward-looking statements, and there is no guarantee that any forward-looking statements will be realized. These important factors include the factors mentioned in the Risk Factors section of Genxi Bio’s recent annual report in Form 20-F, and the discussion on potential risks, uncertainties and other important factors in Genxi Bio’s subsequent report to the US Securities Regulatory Commission after the session. Any forward-looking statements in this statement only reflect the current expectations, and Genxi Bio has no responsibility to publicly update or review any forward-looking statements, whether based on new information, future events or other reasons. Readers are requested not to rely on forward-looking statements after the publication date of this press release.

Media contact

marvin.tang@gracellbio.com

Investor contact

gracie.tong@gracellbio.com

Recently, car home Quanzhou preferential promotion channel has brought a wave of good news! This popular SUV model is undergoing a price reduction promotion in Quanzhou, with a maximum discount of 10,000 yuan. Now buy Haval Xiaolong, the minimum starting price is only 129,800 yuan. If you are interested in this model, don’t miss this rare preferential opportunity. Please click "Check the car price" in the quotation form to get a higher discount!

Haval Xiaolong is a stylish and dynamic SUV with a streamlined front face and a black honeycomb grille. The overall style is very sporty. The body lines are smooth and strong, and the body lines are simple and smooth, which is very atmospheric. At the same time, Haval Xiaolong also uses the headlight group of LED light source, which has excellent lighting effect and improves the safety of driving at night. The side of the car body adopts a double waistline design, which highlights the sense of movement and strength of the car body. The tail design is simple, and the taillight group adopts LED light source, so the overall shape is very fashionable. Generally speaking, the design of Haval Xiaolong is excellent, fashionable and dynamic, showing the personality and pursuit of modern young people.

Haval Xiaolong is a compact SUV with a body size of 4600*1877*1675mm and a wheelbase of 2710 mm. The body lines are smooth and the side lines are simple and atmospheric, which highlights the fashion sense of the car. The front and rear wheel tracks are 1583mm and 1587mm respectively, and the front tyre size is 225/60 R18, and the rear tyre size is also 225/60 R18. The rim of the car body has a unique style and adopts a fashionable shape, which adds a lot of sense of movement to the car. Whether you are driving in the city or traveling long distances, Haval Xiaolong can provide you with an excellent driving experience.

Haval Xiaolong’s interior design is fashionable and simple, with black as the main tone and metal decoration, which highlights the sense of technology and luxury. The steering wheel is made of leather material, which feels comfortable and can be manually adjusted up and down and back and forth to facilitate the driver’s operation. The central control screen size is 12.3 inches, which supports voice recognition control system, and functions such as multimedia, navigation, telephone, air conditioning, skylight and window can be controlled by voice. The front row and the rear row are equipped with a USB/Type-C interface, which is convenient for passengers to charge. The seat is made of imitation leather. The main driver’s seat can be adjusted in front, back and height, the co-pilot’s seat can be adjusted in front, back and back, and the rear seat supports proportional reclining, providing more space and comfort for passengers.

Haval Xiaolong uses a 1.5L 101 horsepower L4 engine with a maximum power of 74kW and a maximum torque of 132 N m.. At the same time, it is equipped with a 2-speed DHT gearbox to provide smooth power output and efficient fuel economy for vehicles.

Thanks to the owner of car home for sharing, his/her evaluation of Haval Xiaolong is very pertinent. As a person with a family, he/she attaches great importance to the practicality of vehicles. Haval Xiaolong’s spacious and comfortable space really brings a good car experience to his/her family. In addition, he/she also mentioned his/her love for the appearance and interior of the vehicle, which is one of the reasons for choosing Haval Xiaolong. Haval Xiaolong’s sleek appearance and high-tech interior have left a deep impression on him/her. Moreover, he/she also mentioned that the cost of using Haval Xiaolong is very low, which is also an important factor he/she considers when buying a car. Haval Xiaolong’s low fuel consumption and low maintenance cost make him/her very satisfied. Generally speaking, Haval Xiaolong is a cost-effective model, which not only has excellent exterior and interior design, but also has excellent practicability and use cost.