From 2012 to 2021, the share of local skin care increased first and then decreased, and the share of local makeup increased by nearly 14pcts； in ten years; At present, the channel and media dividends have faded, local high-quality leading brands have increased investment in research and development, product strength has increased, and high-end has quietly advanced; At the same time, local brands have a deeper understanding of domestic channels and marketing, and local brands have diverted to international high-end brands, and their overall share has entered the bottom area, and their future promotion is expected.

▍ China skin care market: the share of local brands rises first and then falls; At present, the local leading brands are diverging from international high-end brands, and their share is at the bottom.

2012-2021: The share of local skin care increased from 24.8% in 2012 to 34.3% in 2018, and then fell back to 27.7% in 2021; The share of French brands has increased from stable (14% ~ 15% in 2012-2018) to 22.1% in 2021, which is closely related to the strong product strength of French brands and their advantages in sensitive repair and anti-aging. Korean brand share rose first and then stabilized, from 1.2% to 4.5% in 2012-2016, then the mass line weakened but the high-end line increased, and the overall share was stable. Since 2022, many factors such as marketing, channels and local epidemic have caused many changes in the trend. Among them, the local leading companies are becoming increasingly high-end, and the diversion of overseas high-end brands is expected to drive the local share to the bottom.

▍ China makeup market: the share of local brands has been promoted to the leading position, and the high-end has been quietly promoted.

2012-2021: The share of local cosmetics increased from 15.0% to 28.8%, and increased by nearly 14pcts； in 10 years; The share of American makeup decreased from 33.8% to 16.2%, a decrease of 17.6pcts；; After 2016, the share of French make-up increased to 30%+,which is closely related to its advantages in brand heritage, fashion leading and product strength. The share of Korean makeup increased from 7.0% in 2012 to 11.7% in 2016, and then decreased to 8.3% in 2021. Local make-up brands have changed significantly since 2021H2: 1) From fashionable color products (lipstick, eye shadow, etc.) to technical foundation (liquid foundation, etc.), from flow play to brand building; 2) Increase R&D investment, rely on cultural confidence, and strive to catch up with international brands in some sub-categories and product series.

▍ The channel and media dividends faded, and local brands increased investment in R&D, returned to product strength and accumulated brand strength.

Channel change: from 2001 to 2010, CS stores, supermarkets and other brands gave birth to beauty channels; In 2011-2015, the offline was good, the online rose, and the brand enjoyed a double-line bonus; In 2016-2021H, international brands increased rapidly, and new brands emerged; Since 2021H, channel and media dividends have subsided.

Marketing change: from celebrity endorsement to multidimensional grass planting, from big-screen advertising to content marketing and value recognition.

Advanced R&D: In recent years, the brand of skin care of pharmaceutical origin has performed outstandingly, from "medicine" to "makeup", with better quality control and efficacy; Local brands such as Polaiya/Betani/Huaxi /PMPM gather head R&D talents at home and abroad; Synthetic biotechnology promotes the innovation iteration of beauty raw materials, local raw material enterprises flourish, and the curtain of domestic substitution of raw materials opens.

▍ Risk factors:

Discount promotion of international brands suppresses local brands; The relationship between beauty brands and e-commerce platforms is unbalanced; It takes time to accumulate significant results in R&D investment; Scattered epidemic situation repeatedly affects the demand and sales of beauty; Policy supervision strictly affects the growth rate of the industry; The speed and range of domestic substitution of raw materials may not meet expectations.

▍ Investment suggestion:

As a typical optional consumer product, beauty cosmetics have both efficacy and spiritual attributes, with efficacy depending on technology and spirit relying on culture. Local brands increase investment in R&D, and product strength is quietly improved; At the same time, we have a deeper understanding of local channels and marketing. It is expected that the share of high-end and ultra-high-end will increase in the future, which will drive the overall share to rebound. At the present stage of fading dividends and full competition, strong marketing, channels, operational capabilities and sustained high R&D investment are indispensable.

This article comes from financial circles.

Southern Metropolis Daily, November 28th, Edition B01, 08, Education and Health Reader

From November 24th to 25th, the "Guangzhou 2023 Moral Education Forum for Primary and Secondary Schools and Kindergartens" was held in Guangzhou Middle School (Phoenix Campus), with the theme of "Understanding Children and Caring for Growth".

Under the guidance of Guangdong Provincial Department of Education, the forum was hosted by Guangzhou Education Bureau, and undertaken by Tianhe Education Bureau and Southern Metropolis Daily.

[Kindergarten Component Forum]

Children’s mental health education should permeate the activities.

On the morning of 25th, at the kindergarten component forum, front-line teachers from Guangzhou, Shenzhen, Shanghai, Jiangsu and other places shared practical cases, paying attention to the development characteristics and laws of children’s cognition, behavior, emotion and ability …

Encourage children to dare to express their emotions.

"Clap your hands if you feel happy …" In a cheerful clapping song, Li Liming, a teacher of Qinghe Kindergarten in Tianhe District, Guangzhou, brought the lesson of "I Make Friends with Happiness" to share, and 16 children skipped to the stage to share their happy records under the guidance of the teacher.

Li Liming introduced that the teaching object of this activity is middle-class children, who are characterized by rapid development of self-awareness and unstable emotional performance, and will still cry and lose their temper when they are not satisfied. "I don’t know how to express emotions, and I don’t know how to resolve them." Based on students’ psychological characteristics and personality differences, the solution of curriculum design is to create a pleasant atmosphere, such as talking in circles, listening to each other, sharing, etc., to guide children to experience happiness and encourage children to dare to express their emotions.

In the theme sharing session, Li Yarong, director of the kindergarten business of Southern Medical University, brought the sharing of mental health courses. Since 2012, the kindergarten has been exploring children’s sexual health education and deeply cultivating mental health education courses. "Children’s mental health education should permeate various activities and all aspects of activities. For example, environmental creation can be turned into a part of curriculum construction, and quiet areas, secret gardens, private huts, my mood diaries, etc. can be opened at class meetings, so that children can face and deal with their emotions. "

Longing to be seen, felt and understood.

"Changing the perspective of observation and seeing children will have different gains." Niu Ling, the head teacher of Chenkang Kindergarten in Tianhe District, Guangzhou, shared her process of guiding, communicating and understanding Lele’s heart from the perspective of Lele, a "problem child" who likes to swagger and deliberately collide with her peers when walking. "In the thank-you session of the class meeting, when Lele is the star of this week, let other children tell the bright spots of Lele and bring Lele warmth with encouragement from peers." Niu Ling believes that children’s social skills can only be developed if their needs are seen, felt and understood.

Liu Xiancheng, director of Xuri Yayuan Kindergarten in Tianhe District, Guangzhou, has been engaged in early childhood education for more than 20 years. He believes that the only way to truly understand children is to "love you, understand you and accompany you". The kindergarten regularly holds "four-type" parent-teacher conferences to let parents know about their children’s situation in the park, and provide parents with a list of punching cards in streets, districts and cities in combination with the theme of the course, and advocate parents to "see the world" with their children.

"Every year on Children’s Day, let the children bring their parents to the kindergarten to go shopping." "In the game, learn to build your own Hong Kong-Zhuhai-Macao Bridge …" Lin Yongyu, director of the kindergarten affiliated to Guangzhou Kindergarten Normal School, believes that the premise of understanding children is companionship, and the high-quality companionship of teachers, parents and companions is an important force to promote children’s development. Teacher’s companionship is not empty, but should be based on the curriculum implementation process under the corresponding children’s view, which runs through one-day activities in kindergarten, such as military courses and life games.

"Life is education and environment is curriculum"

"Under the big banyan tree, children are laughing, playing with water guns and climbing trees in the rain. We hope that children here can feel their potential through their own exploration." Zhao Jinxia, director of Nantou Ancient City Kindergarten in Nanshan District, Shenzhen, introduced that the kindergarten adheres to the concept of "life is education and environment is curriculum" in the kindergarten-based curriculum construction, and puts the learning task in a real environment, and actively explores and discusses it around the real problem situation with the help of teachers and peers.

Also concerned about the environment of the park is Haibei Kindergarten in Fengxian District, Shanghai. Song Chaoyue, secretary of the Party branch and director of the park, introduced that when the kindergarten was built, it put forward the rules of environmental creation, such as transforming the mountain cement based on experience, effectively connecting the sand pool and the pool, so that children can play the game of sand cement safely and independently; Children and teachers were invited to jointly launch the atrium renovation plan. Under the whimsy of children, a sensory path integrating tiles, tiles and wood blocks was successfully built.

Lv Yan, secretary and director of Zhangjiagang Experimental Kindergarten, believes that "understanding children" is not only a basic skill of teachers, but also an important foundation for establishing a good relationship between teachers and children. "Intention" is the premise and key to understanding children. In August 2018, the kindergarten cooperated with East China Normal University to set up Professor Hua Aihua’s Studio, carried out the practical exploration of "regional game research project", created "let go game" and supported children’s active learning in the game.

In the comment session, Zhang Qiong, director of the Preschool and Comprehensive Education Research Office of the Institute of Basic Education of Guangzhou Education Research Institute, commented on the four major directions of children’s education: the goal, status, field and ecology, and the integration of knowledge and practice. "I have observed that moral education does not occupy an important position in the past curriculum design, which is related to the curriculum form and work characteristics of early childhood education, because it is usually permeated in the dribs and drabs of one-day curriculum, but in fact, moral education is very important because it is the starting point of our whole curriculum."

[Primary School Component Forum]

To be a good teacher is to think about what students are thinking.

In the primary school component forum, school administrators and teachers from Guangzhou, Shenzhen, Shanghai, Zhangjiagang and other places took turns to take the stage to share good methods of moral education in primary schools and explore new ways to care for children’s growth.

In the lesson observation session, Wen Yingying, a teacher from Sihai Primary School in Tianhe District, Guangzhou, held a class meeting with the theme of "Reading Your Hearts and Friendly Communication". Students vividly interpret the verbal friction between classmates in the form of sitcoms. After that, Wen Yingying guides students to think and reflect on the influence of language injury on themselves, classmates and classes. Wen Yingying pointed out that the key to resolving conflicts is to find the unsatisfied basic needs in the heart; Stop the injury and start with mutual understanding.

In the theme sharing session, Zhang Yan ‘en, Party Secretary of Tieyi Primary School in Yuexiu District, Guangzhou, focused on the practical model of "Happiness Micro-moral Education" developed by the school. The school creates a "happiness micro-field" through activities such as "well" graffiti and "box" dressing, making happiness "visible"; Carry out "happiness literacy" micro-classroom, "driving school mobile" micro-school, etc., and do a good job of "happiness micro-course" to make happiness "easy to understand"; Expand the campus "micro-space", pair up with "micro-space" and build a "happy micro-position" so that happiness can be "displayed". "Happiness micro-moral education awakens the positive power in children’s hearts, promotes the healthy growth of children and promotes the all-round development of schools."

The best education is to awaken children’s inner seeds.

"The best education is to awaken the seeds of children’s hearts." Li Ruixiu, head teacher and Chinese teacher of Tianhe No.1 Primary School, pointed out that it is necessary to respect children’s nature, conform to the law of children’s growth and promote children’s health. At the same time, create a good class environment, infiltrate positive education into daily class management, and awaken students’ sense of responsibility for active participation.

Zhang Xiangli, secretary and principal of Haiming School of Sports East Road Primary School in Tianhe District, introduced the construction of a "three-level education system for children", which is to build a school that can "read children, teachers and parents", cultivate a group of teachers who can "read children and parents" and lead a group of parents who can "read children".

"Only by understanding children can we guide children on the basis of better connections." Ouyang Qi, secretary of the Party branch and principal of Tianfu Road Primary School in Tianhe District, said that the school helps children broaden their horizons and participate in practice with reading and courses, and inserts the wings of flying with multi-platform practice as their dream. At the same time, starting from students’ growth confusion, the school develops and designs large class meetings in three periods, which are designed by the host team of the school moral education studio and provided to the class teacher.

He Chunxiu, the principal of the primary school affiliated to Fengxian Middle School in Shanghai, said that to understand children, we must first listen to their thoughts and feelings. To this end, the school implements a full tutor system, and teachers and students match in a two-way ratio of 1: 15, so that tutors can understand children more accurately and provide study and life support.

Teachers should respect children and learn six habits.

Li Wei, the head school of Shenzhen Cuibei Education Group, said that teachers should respect children and learn six habits, namely, listening well, talking well, doing small things well, passing on good books, smiling, trust and hope. "If I were asked to rank the basic skills of teachers, I would definitely give priority to listening to children."

"Children come to school not only to study, but also to live." Liu Hui, secretary of the Party Committee of Zhangjiagang Experimental Primary School, said that since 2018, the school has put forward a new education declaration, "be a bright person and live a normal and active educational life"; Over the years, the school has been committed to building four systems of values, language, aesthetics and intelligence to provide children with better educational content and build an ecological environment and childhood order with higher comfort, freedom and growth.

In the expert review session, Liu Lianghua, a professor at the Institute of Curriculum and Teaching of East China Normal University and the president of Guangzhou Haizhu Second Experimental Primary School Education Group, pointed out that the theme class meeting is a very important starting point for moral education. He was deeply impressed by the forum activities of the day, such as non-violent communication and awakening. He agreed with the views of "the integration of moral education and aesthetic education" and "to be a good teacher is to think about what students are thinking".

[Middle School Component Forum]】

Education is more than just teaching exam-taking skills.

More important is the ability of the church to cope with the future.

At the forum of middle school groups, principals and teachers from Guangzhou, Foshan and Shanghai shared the school’s moral education ideas and practices around "finding love", and experts from Guangdong Primary and Secondary School Moral Education Research and Guidance Center made detailed comments on the sharing.

"Going back to childhood, what is your favorite extracurricular activity?" At the beginning of the group forum of middle schools, Xin Wang, a Chinese teacher of Grade One in Guangzhou Middle School, brought a class lesson "Love to Light up Life". Xin Wang used the experience of Zhang Chenliang in Natural History Magazine to guide the students to think: When the love of life confronts the reality and you are in a dilemma, do you still want to stick to your love? How to choose? At the end of the class, the students wrote down their love on paper and ended the class with the expectation of making love take root.

The education that touches the heart is the real education.

"No’ heart’, no education. Education that touches the heart is the real education. " Cheng Huiyun, executive principal of the Middle Bay School affiliated to Tsinghua University, said that cardiac education makes children learn well. "Heart Education" is an educational action aimed at students’ academic development and physical and mental health. Schools in the Bay Area Attached to the Middle School of Tsinghua University improve the education environment from the aspects of campus environment, curriculum system, management system and teachers’ team, and promote teachers to understand students from their daily teaching actions by understanding the relationship between teachers and students. And create space for students and encourage them to develop their strengths according to their needs.

How does the growth tutorial system help children grow and become talents? Yang Xiaoting, a teacher of Tianhe Foreign Language School, said that since its establishment in 2012, Guangzhou Tianhe Foreign Language School has implemented the growth tutorial system, which helps children find their own love and realize personalized growth by holding double-election meetings between teachers and students, establishing student growth files and implementing the heart-to-heart report system.

How to empower special education through positive education? Autistic children also need special education teachers to understand them. Zeng Jiexin, a special education teacher at Qihui School in Tianhe District, shared her story of promoting students’ understanding of rules through structured teaching and peer learning, and guiding autistic children to cultivate exercise habits and establish peer relationships, helping these children to improve their concentration and execution, while awakening their inner positive strength.

Teach students the ability to cope with the future.

Li Qiang, secretary of the Party Committee and president of Guangzhou Middle School, said that education is not only about teaching exam-taking skills, but more importantly, teaching students the ability to cope with the future. Guangzhou Middle School always insists that every life is illuminated and every voice is listened to. By carrying out the "two sessions" of students, we will listen to students’ opinions on curriculum and teaching management, let students talk about the harvest, difficulties and challenges of each semester, understand their thoughts and give them corresponding guidance and help.

Guangzhou Middle School is also committed to let every child find his own stage and sky. The school helps students to know themselves, find their interests, define their goals and discover more possibilities of life through the implementation of curriculum frameworks such as expanding courses, career planning, academic planning and psychological counseling. "The career system developed by the school can guide students to explore their own hearts and understand their popular ideal careers and ideal universities. Guangzhou Middle School also held a Career Festival’ Career Lecture Hall’ to invite senior professionals from 15 industries including medicine, law, education, finance, culture and art to share their career experiences and professional experiences. "

"The script of high school life is not bitter. How can the same high school be more exciting for three years?" Ding Qikang, Party Secretary and President of Dali Senior High School in Nanhai District, Foshan City, introduced that the school has set up a variety of sports, literature and art, and national defense education activities, attached importance to the parallel development of many characteristics, encouraged all students to actively participate, and let students discover their talents and love in wonderful activities and give play to their personal talents.

Hu Fei, a junior high school Chinese teacher at Chiwan School, the Second Foreign Language School (Group) in Nanshan District, Shenzhen, shared that based on the psychological characteristics of junior high school students and the specific situation of class individuals, courses and activities were built from the two levels of collective education and individual education, combined with the cultural resources of mountains and seas around the school, to help students find their own love.

Love is the best teacher.

Xia Jingjing, deputy secretary of the General Party Branch and president of Hongwen School in Fengxian District, Shanghai, mentioned in the sharing that the school has developed school-based courses, and encouraged students to explore themselves and develop their individuality through project-based learning, comprehensive subject practice activities and student career counseling courses, so that every student can fly like Kun Peng and still dare to pursue dreams under pressure and difficulties.

"Love is the key word of today’s middle school component forum, and love is also the best teacher." At the end of the forum, Zhou Feng, executive director of Guangdong Moral Education Research and Guidance Center for Primary and Secondary Schools, commented on the sharing of moral education practice among schools. He said that a class meeting class and seven special topics sharing in the middle school group closely revolved around the key words, which brought high-quality sharing.

"Reading children is an important starting point to change the phenomenon of attaching importance to wisdom and neglecting morality in education." Zhou Feng emphasized in his comments that the high-quality development of education is not equal to the pursuit of high scores, but is reflected in the overall improvement of students’ literacy. "This requires students to have a strong thirst for knowledge, willpower, a wide range of hobbies, and stimulate students’ learning motivation, cultivate good study habits, and correct their learning mentality. Moral education is the only way to achieve these goals and improve learning efficiency, and it will also serve students’ lifelong happiness. "

Planning: Li Yang

Coordinator: Yin Lai Liang Yanyan Ye Keke You Manni

Written by Southern Reporter Yang Xiaotong Sun Xiaopeng Cheng An Liang Yanyan Ye Siming

Photography: Ma Qiang Technology: Mai Yuxuan

Intern: Ma Yunling Li Hongzhe Design: Zhang Xujun He Xin

On December 1st, the first work "Sleepwalking" developed by Aauto Quicker’s game brand "Finger flick Universe" finally started its first test.

In the eyes of many people, this work represents the highest level of self-research in Aauto Quicker after the game business upgrade. Moreover, Sleepwalking also has a feeling of "the sword is biased" in terms of game types, and chose to build a high DAU product with Roguelite+ARPG as the core.

These factors make Sleepwalking very valuable for research: using GaaS(service game)Is it feasible to make a pure Roguelite?

Let’s look at it bit by bit.

I have to say that Sleepwalking chose an almost perfect theme. In the plot, as a "dream catcher", players have the ability to move freely in dreams, so they will continue to go deep into various dreams to find and solve the secrets and problems of the dream owner-the game therefore adopts the classic narrative method of unit drama+dark line.

In addition, the two concepts of dream and reality, which reflect each other and contradict each other, frequently appear in the plot of the game, which is naturally suitable for discussing various philosophical issues.

For example, in the first chapter of the game, the story discusses the unknown topics about fear and challenge with the help of "deep sea dream";

The second chapter also talks about the concept of money in the dream of getting rich.

With the contrast between exaggerated dreams and reality as the background, players are not so easy to feel "lectured", but more naturally think about life with the game-the plot that allows players to think actively is no worse than those works that rely on adrenaline.

The combat system of Sleepwalking requires players to play three "dream spirits"(role)Each character has three skills: general attack, survival and characteristics. At the same time, each character belongs to one of the six schools, which correspond to different offensive styles, such as melee, barrage, ray, call, encirclement and circle.

At the same time, the "echo" that players get in a single game.（BUFF）Most of them belong to one of these six schools-this setting is easily reminiscent of Hades, and Sleepwalking also draws more lessons from the mechanism of this classic work, such as the design of some rooms and statues that can trigger time-limited challenges and get rewards.

For example, a famous scene like "Xiuluo Field"

Roguelike, a game category, has experienced decades of iteration, and imitation and reference have long been commonplace. The classic Roguelite "Hades" derived from it is also the object of study for many developers. The new knowledge of the game has also been summarized. The imitation of many works only stays at the level of "randomly appearing BUFF by genre", but it can’t "reflect the design sense of the game with random mechanism".

Sleepwalking has made some targeted designs to avoid players being forced to choose the optimal solution, specifically to minimize the importance of "genre theme".

Many similar games are designed with the collocation depth of "1+1>2" in mind, while Sleepwalking emphasizes "2+2=2*2" on the basis of a small amount of "1+1>2": most buffs are designed to add tricks to the player’s character performance, and even some buffs with combined effects will not be so powerful that the player can’t help it after numerical design.

This mechanism also liberates the freedom of players in team matching. There is absolutely no need for the characters in the player’s squad to belong to the same genre, because doing so does not mean higher intensity, not to mention that any two characters in Sleepwalking have a linking effect, which will be triggered after a sufficient number of BUFF are collected in the game.

Under the comprehensive influence of various mechanisms, "Sleepwalking" rarely exerts a sense of anxiety on the player’s role intensity in the process of single game. Players can either plan the specific gameplay in advance and choose the desired construction method tendentiously, or give up thinking after playing the same routine, close their eyes and concentrate on mowing the grass.

This is another design idea. Sleepwalking hopes to directly create a fresh sense of He Shuang with randomness, thus bypassing the hard-core and difficult-to-give-up feature of "players need to learn through constant failure" in fundamentalism Roguelike.

At this time, we should be able to understand more clearly the phrase "sweeping 1.4 billion dreams" when Sleepwalking was published. It doesn’t need many complicated and obscure rules and mechanisms, but it only needs to design different themes and then put them together and collide with each other. The "unrestricted" theme also allows Sleepwalking to give full play to this aspect.

Following this line of thinking, the next problem that Sleepwalking needs to solve is how to effectively show its strengths and let players try more diverse content.

There are still many details that can be polished in a test of Sleepwalking. For example, one of the two sides of the aforementioned "2+2=2*2" is that players will encounter "difficulty in choosing". Let me give an extreme example:

Which one should I choose?

At this time, I thought of Hades, and only a small mechanism was needed to solve the problem.

I don’t believe that we can still choose difficulties in this way.

A big problem in the combination of GaaS and Rougelite is the design of nurturing system: it can increase the depth of the game, but the overweight nurturing system will also make the game deteriorate.

"Sleepwalking" has not become a substantial development game like many Roguelite mobile games. Its cultivation system is very familiar, including role level, skill level, overlapping cards and equipment.

Players who are familiar with the two-dimensional card-drawing mobile game may have begun to feel bad, but in fact, except for the upgrade, the improvement of other cultivation elements is not too great: the full-level skill is only about 50% higher than the initial level, and the player’s most feared card stacking is mainly used to improve the rarity of the role’s corresponding BUFF, and the numerical value is not particularly obvious.

The test of Sleepwalking only lasted less than 4 days. Theoretically, the long-term gameplay does not belong to the focus of this test, but the new knowledge of the game still feels some ideas: grading the gameplay and making the gameplay with lower level become the cultivation process of the gameplay with higher level.

This "lower level" gameplay is the Roguelite main gameplay that we are all familiar with: destroying enemies in fixed-length checkpoints, managing BUFF and resources, and challenging the final BOSS. On the settlement page of the main game after customs clearance, players can choose to save the lineup status at customs clearance to form a "seal".

Imprinting can play a role in other gameplay. For example, there is only one BOSS in the actual process of a short material level. At this time, players only need to choose the pre-saved imprints to directly challenge with the customs clearance team.

This idea can be said to be multi-faceted: special levels create demand for engraving for players, so players get the motivation to play the main mode and explore new construction methods; After a difficult challenge, you can get a new upper limit of material unlocking, forming a spiral play curve.

In addition, Roguelike will force the player to know the progress in the game after a game, which sometimes makes the player feel unfinished-the mechanism of printing can solve this problem to some extent.

Sleepwalking doesn’t look like a game pieced together by randomly selecting several labels. Aauto Quicker’s "highest level" does have something.

I hope Sleepwalking will bring us more surprises in the future.

He added that Liverpool hope to play in the Europa League for most of this season, not the Champions League. But his team arrived at Anfield on Saturday, winning seven games in a row and entering the top four.

"We haven’t been good enough for too long," the German coach said in summing up this season. "I think we made it very exciting. Seven weeks ago, I thought it was impossible. The boys behaved very well in that period.

"I think people like it, too. You can see that they are not angry with us today. They are looking forward to the new Premier League season and the European League season. Me too.

At 8 pm on June 15th, 2023, the world cup champion Argentina men’s soccer team will come to Beijing Workers Stadium to play an international match with the Australian men’s soccer team.

Messi, the king of football, really came to Gundy! Never mind the ticket price, the new workers are going to blow up!

It is a satisfaction for fans to see the skills of the world cup champion with their own eyes. Disappointingly, the China Football Association also announced that the China men’s soccer team will participate in the Dalian International Football Invitational Tournament, while the national team’s opponents will be Myanmar and Palestine.

Messi is very depressed. I went to the national team with the most fans in the world, but they didn’t play football with me.

Why doesn’t the national football team play against Argentina? When the media organizer asked the Football Association, Du Zhaocai said, "There is no need for the national football team to compete with the Argentine national team. This is the confidence of the Football Association." National football team. "This may be to prevent being hit," he said.

On the day of the international football match in June, the second round of the Super League will be cancelled, and Beijing Guoan players will be able to watch Messi in the courtyard.

To put it bluntly, the football match between the national football team and the Argentine national team was disdained by the fans because of the low level of football in China. Or improve your league.

In this week’s Super League, there was a match between Beijing and Shanghai, and Beijing Guoan challenged Shanghai Shenhua away. Ma Ning served as the referee, and football coach jankovic inspected the players on the spot.

From scientist to entrepreneur, Yu Kai is not the first person to "run away" in the field of artificial intelligence.

Despite the previous achievements in scientific research, joining in entrepreneurship means facing the reality of bone feeling.

In March 2015, Yu Kai said in an interview: "If a business can get the resources it deserves to do what it wants, then choose to start a business; If you join a big platform and have more resources to do one thing, then join a big platform. " Sure enough, three months after that, he left Baidu and founded Horizon.

Yu Kai

From the initial "no one pays the bill" to October this year, Horizon successfully won the investment of 2.4 billion euros from Volkswagen, setting the largest single investment record for Volkswagen in the past 40 years, and establishing a joint venture company with audi ag’s software company. The transformation of Yu Kai’s identity can be described as unsuccessful.

Before becoming the founder of Horizon, Yu Kai’s label was the top international scholar in the field of machine learning and the main promoter of deep learning technology in China. His published papers were cited more than 20,000 times, and he won the silver award for the best paper in ICML-2013 International Machine Learning Conference. He himself also served as the domain chairman of ICML and NIPS, two major conferences of machine learning.

Yu Kai’s achievements in the academic field go far beyond this.

NEC Research Institute of the United States was once one of the major centers of international machine learning research. During his tenure, Yu Kai established a highly prestigious technology research and development team in Silicon Valley. This team is one of the earliest and most active teams in the field of deep learning in the world. A series of technologies led and developed by him have pushed image object recognition to a new level worldwide, and won many international famous awards.

After joining Baidu in 2012, the voice technology team, deep learning technology team and image technology team led by Yu Kai won the "Baidu’s highest award" three times in succession, creating records of various technical and business teams within Baidu.

In the eyes of outsiders, Yu Kai at that time, both academically and professionally, was smooth sailing.

But at this time, he chose to start a business.

Yu Kai’s reason is straightforward: "In the past three years, what I have done at Baidu is to promote artificial intelligence in the cloud. But I think there will be a bigger trend in the next few years that I have to do: from artificial intelligence in the cloud to artificial intelligence around everyone. "

Therefore, Yu Kai, who has always believed in "doing things is the most important thing", founded Beijing Horizon Information Technology Co., Ltd. in July 2015, focusing on edge computing in the field of artificial intelligence.

From the moment the company was founded, in his own words: First of all, I will forget that I am a scientist more and more.

To be a scientist, you can put the mainexperienceDo research and write papers, but as an entrepreneur, you should focus more on business and customer needs.

Yu Kai has always wanted to grasp some "truth" things in this process, for example, things that can really create long-term value. With this idea in mind, at the beginning of Horizon’s establishment, he played the slogan of "making brains for machines", and avoided the edge of the field giants, took the edge computing route, and insisted on making AI chips.

It was really hard at first.

When recalling the initial stage of starting a business and determining the development direction, Yu Kai mentioned: At that time, we were predicting a far future, a future that might take 20 years as its dimension. From computers to smart phones, and beyond, what is a bigger computing platform than these? At that time, they were sure,beRobot computing platform. AI chip is the indispensable key to realize this calculation.

Now that we hear about AI chips, it’s needless to say its importance. But when Horizon was founded, not every investor could understand the "blueprint" in Yu Kai’s eyes. As a direct result, the horizon was once unsustainable. Until smart cars become "robots"calculate"The first and biggest landing scene at present, everyone began to understand that Yu Kai had bet on it.

In 2020, smart cars ushered in an outbreak period. As a result, there is a global "lack of core" in the automotive industry.question.

A chip with excellent computing power, like a smart brain, can accurately control the behavior of the vehicle. A series of functions, such as environmental awareness, route planning, driving assistance and so on, advertised by smart cars all need to rely on chips to be realized.

This is also consistent with what Yu Kai has always wanted to do. He has always believed that the real significance of artificial intelligence is not to survive and develop as the opposite of human life, but to support people’s decision-making and enhance their ability. Once the smart car scene is broken down, this ability will definitely spill over to others.floatApplication scenario of robot.

In August 2019, Horizon announced the mass production of China’s first car-class AI chip "Journey 2";

In September 2020, Horizon officially launched the AI chip "Journey 3";

In July, 2021, Horizon released "Journey 5", a high-performance and large-computing, full-scene intelligent central computing chip for the whole vehicle.

……

Yu Kai once said, "The course of a scientist’s entrepreneurship is not based on business opportunities,FromStart in the future. "

This cooperation between Horizon and Volkswagen may be the next future in Yu Kai’s plan.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

Ding Yan Yuhang, a Shandong player who hasn’t updated his personal social dynamics for a long time, recently updated his personal social media. He took a big photo of the China men’s basketball team participating in this World Cup qualifier, and gave his best wishes to his friends. Originally, this was a perfectly normal dynamic, but some fans thought that Ding Yanyuhang was rubbing against the popularity of China men’s basketball team. In fact, it was a bit unfair to Ding Yanyuhang. After all, Xiaoding’s wishes for the national team and friends were sincere, and fans should not be mixed with too much personal feelings.

For Ding Yan Yuhang, some fans also very much hope that he can return to the national team. It is also a great encouragement for Ding Yan Yuhang to see that Abdul Salamu, who has suffered serious injuries like him, has already returned to the national team. Du Feng has also given all players a chance. After all, it is the greatest honor for a player to play for the national team, and it is also a very confidence-boosting thing to have the opportunity to enter the national team after a serious injury.

Recently, there are a lot of news about China men’s basketball team, one of which makes the fans very worried. That is, when qi zhou participated in nbl preseason, many of their opponents were found to have COVID-19. qi zhou, as a close contact, is likely to be isolated and missed. However, recently, some media broke the news that qi zhou appeared in China men’s basketball team’s training abroad, which broke the previous rumor that qi zhou would miss the preliminaries. China men’s basketball team has been sent to the strongest team in the world, hoping that they can break into the final with all their might.

The second phase of the cba is about to start, and wcba has already gone through six rounds. Compared with the attention of CBA in China, there are few fans in wcba. Up to now, three teams in WCBA have maintained an unbeaten record this season, namely the defending champion Inner Mongolia team, Sichuan team and Shandong team. In the first six rounds, Inner Mongolia team beat their opponents by a big score, and their biggest competitor this season is Sichuan team, which is temporarily ranked third.

In fact, after seeing the lineups of the two teams, the fans were not surprised why the two teams competed for the championship. Together, the two teams gathered a total of 17 national players. The Inner Mongolia team gathered 9 national players including Li Yueru, Yang Liwei, Huang Sijing, Zhao Shuang, Zhang Ru, Pan Zhenqi, Ma Xueya, Wei Wei and Li Yifan, while the Sichuan team had Han Xu, Wu Di, Shao Ting, Li Meng, Sun Mengran, Li Shanshan and so on.

In today’s cba league, Guangdong men’s basketball team and Liaoning men’s basketball team are still the two strongest teams. Compared with the 11th championship of Guangdong men’s basketball team, Liaoning men’s basketball team has won the championship of cba league only once, but the runner-up has won many times, which has also been criticized by many fans. Liaoning fans who are very unconvinced listed the past record of Liaoning team, and the time goes back to the national basketball championship in 1985. As we all know, cba league only has a history of more than twenty years. Here

According to the statistics of the fans, since 1985, Liaoning men’s basketball team has won 12 championships in many competitions, such as the National Basketball Championship, the National Basketball League, the National North-South Championship, the National Games, the Asian Club Cup, cba, Extraordinary 12, etc. From this figure, it has indeed surpassed Guangdong’s 11 championships. In fact, just from the data point of view, it can’t explain too many problems. After all, the glory created by our predecessors has become.