BEIJING, June 2 (Xinhua)-Comprehensive US media reported that on June 1, local time, during the graduation ceremony of the US Air Force Academy held in Colorado, US President Biden tripped over the sandbags at the scene and accidentally fell on the podium.

　　Image source: Screenshot of CNN report

　　It is reported that on the same day, Biden was ready to return to his seat after shaking hands with a college student, but he was tripped and fell to the ground. Biden landed on his hips and then supported himself with his hands.

　　Crowds including Air Force Academy officials and two Secret Service agents also rushed forward, grabbed Biden’s arm and helped him stand up.

　　When he stood up, Biden pointed to the place where he tripped and said that something was blocking his way. The video shows that sandbags were placed near where Biden stood.

　　Image source: CNN video screenshot

　　Finally, Biden returned to his seat in the stands. CNN said that at the end of the ceremony, Biden looked in good spirits.

　　The White House said Biden was in good health after his fall. Ben Labert, director of the White House Communications Office, wrote on social media that "(Biden) he is very good. There was a sandbag on the platform when he shook hands. "

　　Former US President Trump quickly responded to Biden’s fall. "I hope he is not injured. The whole thing is crazy … … At the Air Force Academy (falling)? This is not encouraging at all. "

　　Earlier, it was reported that on June 18, 2022, local time, Biden accidentally fell while riding a bicycle near his residence in Delaware, and immediately stood up and said "I’m fine".

　　In addition, Biden fell down several times when boarding Air Force One: in March 2021, Biden fell down twice when boarding the gangway, and the White House explained that it was because of "too strong wind". In May 2022, Biden once again lost his balance when he was preparing to go to Illinois, but he stood firm in time and grabbed the handrail to board the plane. In June of the same year, he almost tripped before taking the opportunity to attend the Summit of the Americas.

　　In February, 2023, Biden ended his visit to Ukraine and Poland, and stumbled again when he returned by Air Force One.

　　On December 30, 2022, Mirai was officially unveiled at the ongoing Guangzhou Auto Show. The new car is Toyota’s first mass-produced hydrogen fuel cell car. According to previous news, the new car was introduced into domestic sales through GAC Toyota, and the first batch was limited to 50 vehicles. The suggested retail price of the market was 748-751,000 yuan.

　　In terms of appearance, the new car was born on the TNGA GA-L rear-drive platform, and its overall shape conforms to the momentum of a medium-sized car. It adopts the latest family design language, and its front face is very close to the styles of this generation of Asian Dragon, Camry and others, with a typical Toyota design language. Although it is not sharp, it is very in line with the aesthetics of the positioning crowd.

　　The front face of the new car is equipped with a trapezoidal air intake grille with variable size and sharp split LED headlights on both sides, which is highly recognizable in the Toyota family. In detail, the front and rear Toyota logos are decorated with light blue exclusive to new energy vehicles, with the "Fuel Cell" badge logo.

　　The side of the car body is slender and atmospheric, the width of the front door is obviously larger than that of the rear door, and the smooth body lines with sharp waistlines have a good sense of movement. In detail, the new car is equipped with large-size multi-frame aluminum alloy wheels, and the window frame of the new car has also been blackened, which looks more capable. Body size, positioning medium-sized cars, its length, width and height reached 4975/1890/1470mm, respectively, with a wheelbase of 2920 mm.

　　The shape of the rear part of the car body is layered, and the duckling tail spoiler is used at the top of the stacked tail, which is closer to ES in overall style. A large amount of black scratch-resistant plastic is used at the bottom of the bumper and a pilot light is embedded in the center, and the exhaust is hidden. The taillights adopt the popular penetrating design, which is highly recognizable.

　　As for the interior, the new car’s interior adopts the embracing cockpit layout, and the center console with asymmetric interior dESign also has family design elements, and its shape is exactly the same as that of lexus es. Large-scale suspended central control panel with LCD instrument and three-position multi-function steering wheel brings rich scientific and technological atmosphere. The cabin materials are wrapped in a large number of soft materials and decorated with chrome-plated decoration in details.

　　In terms of power, the new car is driven by a hydrogen-powered fuel cell. The new fuel cell system has a power density of 3.1kW/L and is equipped with three hydrogen storage tanks, which can store 142.2L (about 5.7kg) of 70MPa high-pressure hydrogen fuel. The maximum power of the motor is 134kW(182 HP), the maximum torque is 300Nm, the cruising range is 781km, and the maximum speed is 175 km/h.

A few days ago, Lynk & Co 08 EM-P added a 120 long battery life Plus model, the official guide price is 195,800 yuan, compared with the original entry-level model 120 long battery life Pro reduced by 13,000 yuan, cancelled 11 configurations. After the addition of new models, Lynk & Co 08 EM-P currently has 6 configuration models on sale, the price range is 19.58-28 8,000 yuan.

In addition, Lynk & Co 08 EM-P also launched a limited-time car purchase discount, from now until the end of April to complete the big order lock order users can enjoy up to 4000 yuan to deduct 20,000 yuan of car purchase rights, which is equivalent to a discount of 16,000 yuan, the whole series of models 179,800 yuan for sale, improve the cost performance.

Although the price of the new model has been reduced, the configuration has also been reduced. Compared with the 120-long battery life Pro, the rear privacy glass, steering wheel heating, front seat massage/ventilation, and 23-speaker audio options have been cancelled. In addition, the anti-dazzling frameless inner rearview mirror has been changed from automatic to manual adjustment, the antibacterial leather steering wheel has been changed to a leather steering wheel, and the Nappa leather has been changed to leather. The three-temperature zone automatic air conditioning has been changed to a dual-temperature zone, and the ESC function of the front seats has been partially reduced.

From the perspective of reduced configuration, it is basically biased towards comfort, while there is no change in the configuration for safety and practicality, such as equipped with 6 airbags, L2-level autonomous driving assistance, full-speed adaptive cruise, 540 ° transparent chassis, electric with memory trunk door, remote start, external discharge, panoramic sunroof, 15.4-inch central control large screen, intelligent vehicle system, etc.

The appearance of the new car is the same as that of the old model. It adopts the design language of the Lynk & Co family, and the sharp lines are matched with the unique shape, which is quite personalized and fashionable. The front face adopts a closed design, and the top is equipped with through headlights and daylight LED daytime running lights, which have a clear taste of the Lynk & Co family and are very recognizable.

From the side, the Lingke 08 EM-P has a very tough temperament, with a bulging waistline and a low front and a high back. In addition, the new car also has a suspended roof, with a large back tail shape, showing the fashion and movement of a coupe SUV. As a new energy model, the Lingke 08 EM-P provides hidden door handles and low wind resistance wheels, which are more visually simple.

In terms of size, the Lynk & Co 08 EM-P is positioned as a medium-sized SUV. The body length, width and height are 4820/1915/1685mm, the wheelbase is 2848mm, and the trunk volume is 545-1277L. The interior space is relatively spacious. Compared with the BYD Tang, its body length is 4870mm and the wheelbase is 2820mm. It has its own strengths with the Lynk & Co 08 EM-P, and the spatial performance is not much different.

In terms of power, the Lynk & Co 08 EM-P is equipped with a 1.5T plug-in hybrid system + 3DHT gearbox, of which the maximum power of the engine is 120kW, the maximum power of the motor is 160kW, the maximum power of the system can reach 280kW, the maximum torque is 615Nm, and it is matched with a 21.2kWh battery pack. Under WLTC conditions, the pure electric battery life is 102km, and the comprehensive fuel consumption is 1.2L/100km.

Write at the end: As a new energy product under Lynk & Co, Lynk & Co 08 EM-P and BYD Tang DM-i are relatively close in terms of model positioning, size space, power life, etc., but they are not as good as Tang DM-i in terms of brand appeal, which affects its market performance. However, for young users who pursue individuality, Lynk & Co 08 EM-P is more fashionable and trendy, and it is also a good choice for plug-in mid-sized SUVs.

Nowadays, consumers pay more and more attention to space when buying a car, and it is worth talking about in terms of space performance. Without further ado, let’s take a look.

Take a look at the appearance of the Envision first. The Envision front looks very dynamic and lively as a whole. The middle net adopts a straight waterfall shape, which is unforgettable. The headlights are simple and the visual effect is very eye-catching. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing, etc. To the side of the body, the body size of the car is 4822MM*1883MM*1705MM, the car adopts fashionable and simple lines, and the side circumference presents a round and lovely design style. With large-sized thick-walled tires, the overall visual effect is very simple. In terms of the rear of the car, the rear of the car and the front face echo each other, the style of the taillights is more fashionable and atmospheric, and the exhaust pipe adopts a bilateral double-out design. The sense of neatness is in front of you.

Sitting in the car, the interior of the Envision looks very cool, reflecting the sense of design. The steering wheel of the car looks very good on the outside, and it is made of genuine leather material, which feels good. Let’s take a look at the central control, which is equipped with a 30-inch touch LCD central control screen, which makes the interior design quite layered. The overall design of the central control is very good. The dashboard and seats are also eye-catching, and the dashboard of the car uses a dual-barrel dashboard, which looks very technological. The car uses leather seats, and the seats are wrapped in place, which further enhances the comfort of the driver and occupant.

Equipped with vehicle to everything, driving mode selection, remote control key, Bluetooth key, rear wipers, interior ambient lights and other configurations, the configuration has reached the mainstream level of the same level.

I have already introduced this car. I believe that many users who buy a car have taken a fancy to its comfort and practicality. If you really want to buy this car, you still need to go offline to experience it.

Hubei Daily full media reporter Zuo Chen, correspondent Zhang Yingying

On November 18, Lantu Automotive Technology Co., Ltd. (hereinafter referred to as "Lantu Automotive") announced the completion of the A round of financing agreement signing and delivery. This round of financing is nearly 5 billion yuan, and the market valuation after financing is nearly 30 billion yuan.

This is the largest first round of financing in China’s new energy vehicle industry to date, which will further optimize the shareholding structure of Lantu Automobile, marking a key step in the marketization of Dongfeng’s high-end new energy brand.

It is expected that more than 40% will be used for technology research and development

According to the disclosure, this round of financing of Lantu Automobile, a total of 10 investors, led by the national team of central enterprises with strategic coordination and large state-owned Financial Institutions Group, state-owned, industrial and private capital actively followed suit.

The joint lead investors are the state-owned enterprise mixed reform fund and Bank of China assets, and the follow-up investors include three state-owned capitals, ICBC Investment, Agricultural Bank Investment, and Jiaoyin Yuanjing, Wuhan Economic Development Fund, Hubei High Quality Development Fund, and Zhongxin High Investment, three local state-owned assets, Ganfeng Lithium Industry and Xinwangda two industries and private capital. Dongfeng Group followed up this financing simultaneously. After this round of financing, Dongfeng Group held 78.88%, A round investors held 12.37%, and Lantu employee shareholding platform held 8.75%.

Lantu Automobile CFO Shen Jun said that this round of financing investors have strategic synergies with Lantu Automobile, especially in the areas of mixed ownership and institutional reform, strategic business collaboration, comprehensive financial services, and three power supply chains. They will achieve resource integration and complementary advantages with Lantu Automobile, and establish a new industrial ecosystem of integration and symbiosis.

The funds will be used to support Lantu’s technology research and development, marketing investment, digital system construction, capacity building and other matters related to the operation and expansion of Lantu’s main business. It is expected that more than 40% will be used for technology research and development. Shen Jun revealed that the company will continue to carry out follow-up financing work as an opportunity. "Based on market and regulatory policies, Lantu will also consider the follow-up IPO plan."

Lu Fang, CEO of Lantu Automobile, said that the financing is based on two considerations. On the one hand, through the introduction of strategic investors to empower, industrial synergies are formed in the upstream and downstream industrial chains, especially Sandian and marketing ecological cooperation, and complementary advantages are realized with investors to further promote the rapid development of Lantu’s business. On the other hand, it is also to continue to implement the relevant requirements of the "double hundred enterprises" mixed reform, improve the corporate governance structure, revitalize the system and mechanism, and further enhance the value preservation and appreciation of state-owned capital, improve the competitiveness of the state-owned economy, and enlarge the function of state-owned capital.

"Fight" in the market wave

As a high-end new energy vehicle brand built by Dongfeng Group, Landmap carries the dual mission of Dongfeng brand upward and exploring new systems and mechanisms, and is a key project for the mixed ownership reform of state-owned central enterprises.

The purpose of the mixed reform of state-owned enterprises is to create a competitive governance system that conforms to modern corporate governance and can cultivate competitiveness and innovation.

Lu Fang said that this round of financing will give full play to the advantages of capital markets in resource allocation, deepen the reform of Lantu’s mixed ownership and system and mechanism, and help Lantu build a more scientific and perfect governance structure, more flexible and efficient operating mechanism, innovation ability and market competitiveness.

"People are the most critical resource for the future development of Lantu Automobile." Lu Fang introduced that Lantu implements flat management and project owner system internally, without departments and calling each other "teachers", coordinated operations, and efficient implementation. Last year, Lantu launched the Equity Incentive Plan for the core backbone of the enterprise, which realized employee stock ownership incentives. After this round of financing, the shareholding of Lantu’s employee stock ownership platform reached 8.75%.

The fast market-oriented response mechanism has allowed Landscape to accelerate since its establishment.

Since the launch of the brand in 2020, Lantu has launched two high-end new energy vehicle products, Lantu FREE and Lantu Dreamer. The third sedan, Lantu Chaser, is expected to debut in December this year, becoming the most complete product layout among China’s new energy vehicle brands. The cumulative layout of 1,771 patents has been applied for, and the patent growth rate is the first in the new energy industry. In September this year, Lantu FREE was officially shipped to Norway, becoming the first new energy national team brand to go overseas.

At present, Lantu Automotive’s R & D personnel account for 38% of the total number of technology companies, and the average age of the team is 32.6 years. The proportion of R & D teams ranks first among new vehicle companies.

Hubei’s competition for a new track adds "weight"

With the "catch-up" of Lantu Automobile in financing, the marketization of new energy brands under traditional car companies has accelerated.

In August last year, Geely Automobile Group’s JK Automobile signed a strategic investment agreement with five prospective investors; in March this year, GAC Aian completed the first introduction of strategic investors; Changan Automobile’s brand Avita was listed on Chongqing’s property rights trading network for the second time; Shanghai Automobile Group’s Zhiji Automobile announced the completion of the A round of equity financing agreement.

"New energy vehicles have become the main direction of the development of the global automotive industry. Whether it is traditional car companies or new car-making forces, they are increasing investment in the field of new energy." Lu Chihua, a professor at the School of Automotive Engineering of Wuhan University of Technology, said that the current round of financing of Lantu Automobile has many leading companies in the industrial chain, which will form a joint force for industrial competition.

For example, the state-owned enterprise mixed reform fund is approved by the State Council, and the State-owned Assets Supervision and Administration Commission of the State Council has entrusted China Chengtong Holding Group Co., Ltd. to initiate the establishment of a national fund, focusing on the layout of national strategic emerging, technological innovation and mixed ownership reform in key areas of the industrial chain; Ganfeng Lithium Industry and Xinwangda are both leading enterprises in the field of lithium batteries.

Lu Chihua said that this not only means that Lantu Automobile will get more "ammunition" and work with industry partners to create more in line with market demand and more competitive products, but also means that it has the ability to represent the entire Wuhan, and even Hubei, to participate in the national and even world competition in the new energy vehicle market.

Lu Fang, CEO of Lantu Automobile, said that the current international economic situation is severe, and various unfavorable factors are superimposed, making it more difficult to invest and finance in the automobile and parts industry. However, Lantu Automobile’s success in "leading the war" reflects the full recognition and confidence of investors in the primary market for the investment value of Lantu Automobile, and also shows that Lantu Automobile has super strength and unique advantages in the high-end intelligent electric vehicle track.

On April 25, 2018, the new Hongqi H5 was officially launched at the Beijing Auto Show, priced 14.98-19 5,800;

As a Chinese high-end brand B-class car, Hongqi H5 has the advantages of fashionable and dynamic shape, strong intelligence system, extreme safety, strong power and excellent handling;

With the ultimate products and the ultimate service, the Hongqi brand will strive to meet consumers’ pursuit of "wonderful travel, beautiful life".

Finally waiting for you!

On April 25, 2018, the Hongqi H5, a B-class luxury sedan built by China FAW Group, was launched at the Beijing Auto Show! Olympic champion Wu Dajing also made an appearance at the press conference, becoming the first owner of the Hongqi H5!

Zhilian Royal Mobile Edition 195,800 yuan;

Zhilian Enjoy Dynamic Edition 185,800 yuan;

Zhilian Yundong Edition 175,800 yuan;

Zhilian Smart Edition 165,800 yuan;

The movable version is 149,800 yuan.

The red flag of the new era is a different red flag. As the first Chinese high-end brand B-class car, the Hongqi H5 will shape the new pattern of the B-class car market with its strong strength of beauty and materials.

On the day of the launch of the Hongqi H5, Xu Liuping, chairperson of China FAW Group Co., Ltd., said: "At present, we Hongqi people are adhering to this concept and spirit, insisting on pioneering and innovating, striving for excellence, and striving to create Chinese-style new noble and exquisite products and services. I firmly believe that in the near future, we will have more achievements and surprises to share with you. Please wait and see and enjoy the products and services of Xinhongqi to the fullest."

As the first owner of the Hongqi H5, Wu Dajing said: "Seeing the Hongqi H5 today can be said to have a bright feeling. In the past, in my impression, the Hongqi was luxurious, noble and atmospheric, but it was also more traditional, serious and heavy, but I didn’t expect the design of the Hongqi H5 to be so young, fashionable and down-to-earth."

Stunning appearance, excellent interior, Hongqi H5 shows off

As a benchmark for high-end B-class cars of "sharp and new", China FAW has given the Hongqi H5 an absolutely high-value appearance and excellent interior. The Hongqi H5 is stylish and dynamic in shape, whether it is a family-style straight waterfall air intake grille, eagle-wing LED headlights, a lean back-style tail design, or an intelligent and simple interior, all of which fully conform to and highlight the aesthetic propositions of the younger generation.

In terms of interior materials, workmanship, and other details, the Hongqi H5 also exhibits a very high standard.

For example, the center console adopts North American imported white bolt wood solid wood trim with tough texture and fine and clear texture. The seats are made of Australian imported bull leather, using full-grain technology, and have undergone fine stitching and punching. The whole car is also equipped with 11-speaker BOSE audio, which makes for a wonderful audio experience in the palace.

The R & D team of Hongqi H5 also pursues the ultimate in terms of interior refinement and luxury perception quality. The whole car has carried out more than 1,100 fine and benign optimizations. For example, the center console knob of Hongqi H5 adopts a pineapple pattern chamfer design that requires extremely high detail processing technology. In addition, in many details such as the top light, the instrument panel pointer, the sewing process of the seat, and the adjustment of the softness and hardness of the seat, Hongqi H5 has buried "easter eggs" for users.

Powerful intelligent control brings a new era of intelligent experience

The new Hongqi H5 also has powerful intelligent control technology: including mobile phone remote control, night smart headlights, two-color ambient lights, automatic parking, fully intelligent voice assistant, and interesting and rich entertainment social interconnection systems such as "want to listen", "want to chat", "bullet comment", "red envelope", etc., to bring users the ultimate comfortable experience.

Never compromise on safety! Create top-level safety and excellent driving control

The Hongqi H5 is equipped with a 1.8T turbocharged engine, and the chassis has been precisely adjusted to provide consumers with a smooth driving experience.

All good things require safety escort. Hongqi H5 is equipped with Bosch 9.3 generation ESP system, AEB active braking system, IHC intelligent headlights, BLIS blind spot monitoring system and ACC adaptive cruise system and other all-round active and passive safety protection.

The channel makes rapid progress and presents the ultimate service

As an important part of the new Hongqi strategy, a sound channel is one of the key factors for the development of the Hongqi brand. The first batch of 62 Hongqi experience centers was fully completed and opened along with the listing of Hongqi H5. The "Hongqi Tmall Flagship Store" and Hongqi Cloud Store were also opened at the same time, opening an innovative market model that combines online and offline of the Hongqi brand. In addition, in 2018, more than 100 Hongqi experience centers will be completed, and by 2020, this number will become 170.

With the Hongqi Experience Center as the carrier, the Hongqi brand provides consumers with "Hongqi Heart Service" covering the entire vehicle cycle. Hongqi H5 owners will enjoy three super services of "Lifetime Free Warranty", "Lifetime Free Rescue" and "Lifetime Free Pickup and Delivery", which are the first in the industry. You can also enjoy the "+ 1 Used Car Value Preservation Plan". In addition, in the future, Hongqi owners will also enjoy the ultimate travel services such as Hongqi VIP lounges at large airports and high-speed rail stations across the country.

The new strategy is gradually implemented, and the red flag accelerates the road to revitalization

All the excitement comes from FAW’s firm belief in building Hongqi into "China’s first and world-famous new noble brand". With the launch of the new Hongqi H5, Hongqi not only brings consumers a higher quality product experience, but also accelerates the further implementation of the new Hongqi brand strategy. At the same time, FAW will also play its role as a leader in Chinese auto companies, lead Chinese brands as a whole, and create a new era for China’s auto industry!

Regarding the Hongqi brand:

The Hongqi brand is a high-end sedan brand under China FAW, which is directly operated by the headquarters of China FAW Group.

For the Chinese, Hongqi is not only a famous car brand, but also a deep feeling and sacred memory. For FAW people, Hongqi is a strong responsibility and historical mission. In 1958, the Hongqi brand car was born. Since then, Hongqi has become a state vehicle for national leaders and major national events. In the 1960s and 1970s, Hongqi cars became a flag of China’s automobile industry. After the reform and opening up, Hongqi continued to undertake the heavy responsibility of "national car" while beginning to continuously impact in the direction of marketization and commercialization. On January 8, 2018, China FAW released the new Hongqi brand strategy.

Regarding the brand strategy of Xinhongqi:

New Hongqi Brand Concept: Chinese New Noble Exquisite

New Hongqi will highlight the concepts of "new nobility", "new delicacy" and "new feelings", and deeply integrate Chinese traditional excellent culture with world advanced culture, modern fashion design, cutting-edge science and technology, and fine emotional experience to create excellent products and services.

? New Hongqi Target customers: Chinese-style new noble people

? Xinhongqi’s strategic goal: to build Xinhongqi into a "new noble brand" that is "China’s first and world-famous", to meet consumers’ pursuit of "better life and wonderful travel" in the new era, and to shoulder the important task of a strong Chinese automobile industry entrusted by history.

? New Hongqi product series: The New Hongqi family will include four series of products: L, S, H, and Q.

L series, the new noble red flag supreme car; S series, the new noble red flag coupe; H series, the new noble red flag mainstream car; Q series, the new noble red flag business vehicle.

?

Suzhou, China, Palo Alto, California, USA May 20, 2021/PRNewswire/-Genxi Biotechnology Group (NASDAQ: GRCL；; Genxi Bio, a global clinical biopharmaceutical company dedicated to developing efficient and economical cell therapy for cancer treatment, announced today that it will publish the latest clinical research results of a multi-center, first-time human trial on GC012F in the treatment of relapsed/refractory multiple myeloma during the annual meeting of American Society of Clinical Oncology (ASCO) in 2021 and the conference of European Hematology Association (EHA) in 2021.

GC012F is a BCMA/CD19 dual-target autologous CAR-T cell therapy developed based on the patented technology platform of Genxi Bio-FasTCAR, which has the advantage of "production can be completed the next day". At present, the candidate product is being evaluated in a phase I clinical trial initiated by researchers.

• By January 12, 2021, 19 patients with multiple myeloma were enrolled in the three dose groups of this study, of which the highest dose level was 3×10.^fiveCells/kg body weight, all the above patients meet the criteria of recurrence/refractory after multiple rounds of treatment. Subsequent patients (after the release of data at the ASH annual meeting in 2020) received the highest dose level of treatment.
• The early objective remission rate (ORR) was as high as 94.7%(18/19), and all the responses showed that excellent partial remission (VGPR) and even complete remission (SCR) were obtained. The data of all dose groups showed a rapid, in-depth and lasting therapeutic effect.
• All patients (n=9) who received treatment in the highest dose group achieved negative minimal residual lesions-complete remission (MRD- sCR) in a strict sense.
• Of the 19 patients, 18 (94.7%) belonged to the high-risk patients defined in mSMART 3.0 guidelines, and the median number of previous treatment lines was 5.
• 94.7%(18/19) patients have been exposed to PI, IMiD and at least the third treatment scheme, including anti-CD38 targeted therapy.
• The safety of GC012F is consistent with the previous observation results, and the main symptom is low-grade cytokine release syndrome (CRS)(84% patients are grade 1/2; 11% (n=2) patients were grade 3), and there was no grade 4 or 5 CRS；. No immune effector cell-related neurotoxicity (ICANS) was observed in 19 patients. Adverse events (TEAEs) occurred during treatment were mainly manifested as decrease of blood cell count and increase of AST. All TEAEs were relieved after standard treatment.
• The study will continue to evaluate the effectiveness and safety of GC012F in the treatment of patients.

"I am glad to see the mutual evidence between the follow-up of the initial patients and the treatment effect of the subsequent patients, which not only confirms the research results announced at the annual meeting of ASH last year, but also further clarifies the excellent safety and effectiveness of GC012F dual-targeted autologous CAR-T cell therapy, including for high-risk patients."Chief Medical Officer of Genxi BiologydoctorIt said: "High-risk patients are usually extremely difficult to treat, but all patients in the highest dose group in this study have reached the MRD negative sCR state and maintained a deep response for six months or even longer after receiving GC012F infusion. The above exciting research data bring brand-new hope to high-risk patients (including those who do not respond to the standard treatment plan). Next, we plan to promote this research on a global scale, including promoting it as a more preferred treatment option. I look forward to sharing more developments with you in the near future. "

GC012FClinical research initiated by researchers (IIT) Co-principal researcher, Professor Du Fu of shanghai changzheng hospital."Multiple myeloma (MM) is a malignant blood tumor that is extremely difficult to treat. There are about 750,000 patients with multiple myeloma worldwide.^[1]There are about 160,000 new patients every year.^[2]And it is on the rise year by year. Among them, high-risk patients account for 20%-30%.^[3]The prognosis is usually poor, accompanied by higher risk of early recurrence, shorter progression-free survival and overall survival. This time, we are pleased to see that the BCMA/CD19 dual-target autologous CAR-T cell therapy GC012F of Genxi Bio has shown excellent effectiveness and safety for the long-term follow-up results of patients with relapsed/refractory multiple myeloma. And thanks to the advantages of FasTCAR platform, the waiting time of clinical treatment has been significantly shortened, and the hope of life has been ignited for more patients. "

GC012FClinical research initiated by researchers (IIT) Co-principal researcher, Professor Fu Weijun of shanghai changzheng hospital.Said: "I am very happy to see that after we announced the first human trial data of GC012F in the form of oral report at the ASH meeting last year, this research has made positive progress again, and the previous results have been further verified; This also allows us to see the good application prospects of Ganxi Bio-FasTCAR platform and Dual CAR technology. With the deepening of research, the clinical benefits of this innovative BCMA/CD19 dual-targeted autologous CAR-T cell therapy for patients with multiple myeloma, especially high-risk patients, are constantly emerging. It is expected that this research will continue to achieve more results and strive to meet the urgent treatment needs of patients with recurrent/refractory multiple myeloma as soon as possible. "

Details of the electronic poster are as follows:

2021American Society of Clinical Oncology (ASCO) annual meeting

abstract8014：Long-term follow-up results of the first multicenter human trial of BCMA/CD19 dual-target CAR-T cell therapy GC012F for patients with relapsed or refractory multiple myeloma based on FasTCAR platform.

Poster release date:June 4, 2021

2021European hematology association (EHA2021) conference

abstractEP962：Long-term follow-up results of the first multicenter human trial of BCMA/CD19 dual-target CAR-T cell therapy GC012F for patients with relapsed or refractory multiple myeloma based on FasTCAR platform.

Poster release date:June 11th, 2021

About multiple myeloma

Multiple myeloma (MM) is the third most common malignant hematological tumor in the United States. Its tumor cells originated from bone marrow plasma cells, an immune cell responsible for secreting anti-infective antibodies. About 160,000 patients worldwide are diagnosed with multiple myeloma every year; In 2020, the United States is expected to have more than 32,000 confirmed patients. In recent years, although many progress has been made in the treatment of multiple myeloma, the clinical treatment effect is still unsatisfactory. International Myeloma Working Group (IMWG) and the consensus guidelines of Mayo ST Rating for Myeloma and Risk-Adapted Therapy (MSMART) classify patients with specific cytogenetic abnormalities or other abnormalities as high-risk patients, and this group accounts for 20-30% of all patients with multiple myeloma. High-risk patients with high risk of early recurrence, progression-free survival and short overall survival are considered as the most difficult patients with multiple myeloma, and usually have poor prognosis.

aboutGC012F

GC012F is a candidate product for dual-target autologous CAR-T therapy based on FasTCAR platform. At present, the candidate product is evaluating its safety and effectiveness in the treatment of multiple myeloma in a multi-center and phase I clinical trial initiated by researchers, covering many research centers in China. GC012F brings rapid, in-depth and lasting therapeutic effects to patients with multiple myeloma by simultaneously targeting the malignant plasma cell site expressing BCMA and the early progenitor cell site expressing CD19.　

aboutFasTCAR

FasTCAR is a technology platform with intellectual property rights of Genxi Bio, aiming at developing high-quality autologous CAR-T cell therapy. Preclinical studies show that the phenotype of CAR-T cells produced by FasTCAR technology platform is younger, the degree of depletion is lower, and the amplification ability, persistence, bone marrow migration ability and tumor cell clearance activity are enhanced. With the advantage of "completing production the next day", FasTCAR platform technology can greatly improve cell production efficiency, thus significantly reducing production costs and enabling cell therapy to benefit more cancer patients.

About genxi creatures

Genxi Biotechnology Group (Genxi Bio for short) is a global clinical biopharmaceutical company dedicated to the discovery and development of breakthrough cell therapy. Using its pioneering FasTCAR and TruUCAR technology platforms, Genxi Bio is developing a number of rich clinical cancer treatment product pipelines, both autologous and allogeneic. These products are expected to overcome the persistent major industry challenges of traditional CAR-T therapy, including long production time, poor production quality, high treatment cost and lack of effective treatment for solid tumors. To learn more about Genxi Bio, please visit www.gracellbio.com/ Concern LinkedIn account @GracellBio.

Warning statement about forward-looking statements

The statement in the press release about future expectations, plans, prospects and other non-historical facts may contain a "forward-looking statement" as defined in the Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements related to the expected transaction and completion time of this offering. These statements may, but do not necessarily, contain the following words and corresponding negative forms or similar words: purpose, expectation, belief, estimation, prediction, plan, possibility, prospect, plan, potential, conjecture, formulation, seeking, possibility, should and will. Due to various important factors, the actual results may be significantly different from the forward-looking statements, and there is no guarantee that any forward-looking statements will be realized. These important factors include the factors mentioned in the Risk Factors section of Genxi Bio’s recent annual report in Form 20-F, and the discussion on potential risks, uncertainties and other important factors in Genxi Bio’s subsequent report to the US Securities Regulatory Commission after the session. Any forward-looking statements in this statement only reflect the current expectations, and Genxi Bio has no responsibility to publicly update or review any forward-looking statements, whether based on new information, future events or other reasons. Readers are requested not to rely on forward-looking statements after the publication date of this press release.

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　　 China Youth Daily Zhongqing Online Reporter Dong Zhicheng

　　 In Qingdao in July, the sun is like fire. On the 23rd, a delegation from the online media National Defense Bank of "Building a Strong Military Dream Together" came to an independent regiment of the North Sea Fleet Aviation. It is reported that the regiment is the first ship-borne helicopter unit of the whole army, and the first emergency mobile combat unit determined by the Central Military Commission, which is mainly responsible for missions such as searching and attacking submarines, over-the-horizon guidance, attacking ships, fighting and transporting, and maritime rescue.

　　 In the fighting spirit cultivation center, the reporter was shocked by a world map that marked dozens of major mission routes of the regiment: half a century’s stormy journey, generations of carrier-based aircraft people, driving Hawk to fly high into the deep blue, drew the glorious track of the first carrier-based aircraft unit of the China Navy.

　　 Yu Zhigang, the "Antarctic Eagle": Braving the Antarctic Forbidden Zone

　　 Antarctica has always been recognized as a "white death line" by the international aviation community. After 25 years of investigation in Antarctica by a developed country, more than 50 planes died in glaciers. In November, 1984, an independent regiment of the North Sea Fleet Air Force, Yu Zhigang, set sail for the Antarctic with the No.179 Super Hornet helicopter to carry out the Antarctic investigation and station building mission.

　　 The climate in Antarctica is very bad, and every flight is a handshake with "Death". In this mission, 17 flight days were organized, 104 flights were safely taken off and landed, 39 tons of materials were lifted, and 1,050 people were carried, without any mistakes.

　　 In the 12 escort missions, at the moment of taking care of the hostages, the picture shows the crew who took back the first flight jumping off the plane.

　　 Cheng Wengang: Taking risks to take care of the 26 crew members of "Xufu No.1"

　　 In July, 2012, during the 12th escort mission to Somalia in the Gulf of Aden, Cheng Wengang, a pilot of a ship-borne helicopter, was ordered to go deep into Somalia to take care of the crew of Taiwan Province Xufu No.1 who had been hijacked by pirates for more than 19 months. In the critical situation that the wind force was 8 and the wave height was 6 meters, and the two boats sent in the early stage were overturned and could not be approached, the helicopter took off beyond the conditions and went straight to the pirate’s lair at the risk of being attacked at any time at night.

　　 "Report to the command post that the released crew members have been found and ask for help." After receiving the agreed reply from the command post, Cheng Wengang carefully manipulated the helicopter and began to look for the landing site.

　　 A wet beach about 10 meters wide exposed after low tide caught Cheng Wengang’s attention. "It can be used as a landing site." He immediately used the method of hovering for half a meter and soft grounding on the right wheel, and flew six sorties successively to safely rescue 26 Chinese and foreign hijacked crew members.

　　 Luo Dechang, an ordnance engineer who was on the helicopter at that time, told the China Youth Daily and Zhongqing Online reporter that the crew’s eyes were filled with tears and their mouths kept saying "thank you" when the hatch was opened.

　　 Liu Peng: The real eagle is trained in fighting with wind and rain.

　　 Liu Peng, the squadron leader of Flight 3, was carrying out the sixth batch of Somali escort mission in the Gulf of Aden when a suspicious speedboat suddenly appeared in the left front of the formation. The formation ordered the Liu Peng crew to take off urgently and drive away. The helicopter crew quickly approached the tracking target, and when it was less than 1 km away from the pirate speedboat, it quickly lowered its altitude and fired two shock bombs to warn it to drive away. However, the suspicious target did not stop and still approached the protected merchant ship.

　　 Liu Peng decisively manipulated the helicopter to reduce the height to 100 meters, which was within the range of pirate weapons. Everyone’s heart suddenly hung up, and the special warfare players quickly stopped shooting at the pirates with machine guns. In the face-to-face confrontation with the pirates, the pirates finally turned around and disappeared into the vast sea under pressure.

　　 According to reports, since its establishment, the regiment has successfully completed such major tasks as salvaging the launch vehicle data module, building an Antarctic scientific research station, aerial survey of submarine-launched missiles, Olympic security, multinational naval activities, ocean escort, etc. issued by the CPC Central Committee and the Central Military Commission, winning honor for the motherland and the people, and gaining the reputation of being a "pioneer in air and sea".

　　At the closing ceremony of the 2008 Olympic Games, 18 districts and counties in Beijing will set off fireworks together to record this historic moment, so that gorgeous Beijing and happy Beijing will go down in history forever. The fireworks feast at the closing ceremony and the Bird’s Nest will surely become the focus of world attention. To this end, Xinhuanet specially invited Zhao Weiping, the general commander of the Bird’s Nest fireworks display, to introduce the related situation of the Bird’s Nest fireworks display at the closing ceremony.

Zhao Weiping, the general commander of the 2008 Olympic Games Bird’s Nest fireworks display, was interviewed by this reporter.

　　Zhao Weiping: Everything is ready for the fireworks display at the closing ceremony.

　　Moderator: The expected closing ceremony is about to be staged. Apart from the rich programs prepared by ourselves and the 8-minute performance in London, the fireworks will bring the atmosphere of the audience to a climax. What is the preparation for the fireworks in the closing ceremony?　

　　Zhao Weiping: We have basically finished the preparations for the closing ceremony. There are 420 launching sites and 8,138 fireworks in the closing ceremony. It is necessary to rearrange the layout and rearrange the launcher. At present, the preparations include the installation of fireworks, the structural installation and wiring of the shelves. The rest of the time we will do some tests on them and check them a few more times to be foolproof.　

　　Moderator: Will some equipment at the opening ceremony continue to be used at the closing ceremony?

　　Zhao Weiping: The equipment that is exactly the same as the opening ceremony is gone. They have all been readjusted. Because each launcher actually involves different specifications and quantities, basically nothing used in the opening ceremony can be used in the closing ceremony. We hung many launchers again and rearranged them, because after all, the products are still very different. This is the difference between the opening ceremony and the closing ceremony.

　　Moderator: The Bird’s Nest has been in the competition all the time, and the performance place of the closing ceremony is also in the Bird’s Nest, which is bound to bring some difficulties to the preparation of fireworks. What difficulties have you encountered? How do we overcome it?

　　Zhao Weiping: The biggest problem encountered in the construction of the closing ceremony is that the construction is not allowed during the day, and the other is that it rained heavily two nights ago, which brought us some difficulties and increased the intensity of our work. Our team basically worked all night every day. In addition, there is no light on the bird’s nest at night, and we mainly rely on the peripheral auxiliary lights to illuminate the work, which also increases the difficulty of our work. But even under such circumstances, everyone made unremitting efforts, especially the encouragement brought by the success of the Olympic opening ceremony. It should be said that the whole team is United as one and has high morale, hoping to complete the closing ceremony successfully.

　　Moderator: Our staff is still in a very good state, without any slack?

　　Zhao Weiping: No. We also held a mobilization meeting yesterday, which was the last mobilization before the closing ceremony. I hope everyone can make a great effort to make the closing ceremony beautiful. After these mobilizations, everyone is still very active. Everyone performed very well, and I was very touched. I think it must be the fighting spirit of the Olympic Games that encouraged everyone. I am very satisfied with the performance of the team, as a person, as the leader of the enterprise or as the commander-in-chief of the fireworks display team.

　　Moderator: This time, the preparation is quite adequate, but the closing ceremony has not been rehearsed. Will you feel a little insecure?

　　Zhao Weiping: No, because as the closing ceremony itself, there is no substantive rehearsal, but every discharge in front of the Bird’s Nest can be said to be a rehearsal for the closing ceremony. Because each discharge and installation will bring more experience, more protection and more confidence to the next one.

The staff installed the Bird’s Nest fireworks in the daytime and at night (picture provided by Panda Fireworks Company).

　　The fireworks of "Xiangyun", the first appearance of the closing ceremony, will ignite the night of passion.

　　Moderator: Then can you tell us specifically what kind of fireworks will be displayed at the closing ceremony?

　　Zhao Weiping: There are still some differences between the closing ceremony and the opening ceremony. Everyone has seen the opening ceremony. There are five rings, footprints, some beautiful wings on the top of the bird’s nest, doves of peace, countdown in the stadium, waterfalls, lightning, thunder, including the peony flowers we talked about, and dynamic five-color rings, all of which have their own characteristics. We also used the chip bomb (which is the most advanced in the world at present) and used air launch for the first time. These are the results of our technological innovation.

　　Our main product innovation at the closing ceremony is an auspicious cloud. As we all know, Xiangyun has spread all over the world, and we also hope that the creativity of fireworks can be expressed by Xiangyun, which may be different from our Xiangyun torch. There will be spiral and dynamic fireworks at dozens of points on the top of the bird’s nest, which has never been seen before. Xiangyun has two colors, including a gold one. This is a relatively good product, and it took us about half a year to develop it after receiving the task book from the Olympic Organizing Committee.

　　Another highlight of the closing ceremony is that we have a colorful circle on the top of the Bird’s Nest. After typing, you will see a fireworks circle, which is quite beautiful, and it has been launched twice. We didn’t have such a variety in the last opening ceremony. It exploded in the sky after you hit it from below and saw the effect. The products we used at the opening ceremony last time did not explode in the sky, but this time there will be an explosion in the air, which will present a very beautiful scene and bright colors. At last, a round pattern made by a big fireworks will be formed on the periphery of the bowl at the top of the Bird’s Nest. I think this round pattern also indicates the complete success of the whole Olympic Games, which can also be said to be "round and full". Everyone is happy and safe. The Olympic Games shows her moral through these fireworks, so I think these will also bring you some aesthetic feeling and some new visual impact. The other difference between the closing ceremony and the opening ceremony is that we have more dynamic things running fast on the top of the bird’s nest in the closing ceremony.

　　Moderator: So what is the scale of the fireworks display at the closing ceremony?

　　Zhao Weiping: From the top of the Bird’s Nest, the whole scale of fireworks in the closing ceremony is smaller than that in the opening ceremony. This time, we don’t have bowl products, which means that there is nothing inside the Bird’s Nest, and the part outside the Bird’s Nest is basically the same as that in the opening ceremony.

　　Closing Ceremony The Beijing Municipal Government and the Olympic Organizing Committee hope that the whole city will have an opportunity to celebrate together and hold fireworks celebrations in 18 districts and counties in Beijing, because after all, it was almost seven years since we won the right to host the Olympic Games in 2001, and many people all over the country worked hard for it. On the whole, this scale is unprecedented in Beijing’s history, and it can be said that there is no such scale in the world. At that time, after the closing ceremony, fireworks will be lit in 18 districts and counties at the same time. I think this can be applied for Guinness Book of Records, which has never been seen in any city or at any time in the past.

　　The fireworks display at the closing ceremony is not affected by rain.

　　Moderator: If it rains on the closing day, will it affect the fireworks display?

　　Zhao Weiping: This is no problem. Because we have already installed the fireworks, it can be said that the problem of rain has been solved at this stage, and it will not be affected whether it rains or other circumstances. If it rains heavily, of course we will listen to the organizing Committee, but as far as I know, it won’t rain before the 24th.

On December 1st, the first work "Sleepwalking" developed by Aauto Quicker’s game brand "Finger flick Universe" finally started its first test.

In the eyes of many people, this work represents the highest level of self-research in Aauto Quicker after the game business upgrade. Moreover, Sleepwalking also has a feeling of "the sword is biased" in terms of game types, and chose to build a high DAU product with Roguelite+ARPG as the core.

These factors make Sleepwalking very valuable for research: using GaaS(service game)Is it feasible to make a pure Roguelite?

Let’s look at it bit by bit.

I have to say that Sleepwalking chose an almost perfect theme. In the plot, as a "dream catcher", players have the ability to move freely in dreams, so they will continue to go deep into various dreams to find and solve the secrets and problems of the dream owner-the game therefore adopts the classic narrative method of unit drama+dark line.

In addition, the two concepts of dream and reality, which reflect each other and contradict each other, frequently appear in the plot of the game, which is naturally suitable for discussing various philosophical issues.

For example, in the first chapter of the game, the story discusses the unknown topics about fear and challenge with the help of "deep sea dream";

The second chapter also talks about the concept of money in the dream of getting rich.

With the contrast between exaggerated dreams and reality as the background, players are not so easy to feel "lectured", but more naturally think about life with the game-the plot that allows players to think actively is no worse than those works that rely on adrenaline.

The combat system of Sleepwalking requires players to play three "dream spirits"(role)Each character has three skills: general attack, survival and characteristics. At the same time, each character belongs to one of the six schools, which correspond to different offensive styles, such as melee, barrage, ray, call, encirclement and circle.

At the same time, the "echo" that players get in a single game.（BUFF）Most of them belong to one of these six schools-this setting is easily reminiscent of Hades, and Sleepwalking also draws more lessons from the mechanism of this classic work, such as the design of some rooms and statues that can trigger time-limited challenges and get rewards.

Roguelike, a game category, has experienced decades of iteration, and imitation and reference have long been commonplace. The classic Roguelite "Hades" derived from it is also the object of study for many developers. The new knowledge of the game has also been summarized. The imitation of many works only stays at the level of "randomly appearing BUFF by genre", but it can’t "reflect the design sense of the game with random mechanism".

Sleepwalking has made some targeted designs to avoid players being forced to choose the optimal solution, specifically to minimize the importance of "genre theme".

Many similar games are designed with the collocation depth of "1+1>2" in mind, while Sleepwalking emphasizes "2+2=2*2" on the basis of a small amount of "1+1>2": most buffs are designed to add tricks to the player’s character performance, and even some buffs with combined effects will not be so powerful that the player can’t help it after numerical design.

This mechanism also liberates the freedom of players in team matching. There is absolutely no need for the characters in the player’s squad to belong to the same genre, because doing so does not mean higher intensity, not to mention that any two characters in Sleepwalking have a linking effect, which will be triggered after a sufficient number of BUFF are collected in the game.

Under the comprehensive influence of various mechanisms, "Sleepwalking" rarely exerts a sense of anxiety on the player’s role intensity in the process of single game. Players can either plan the specific gameplay in advance and choose the desired construction method tendentiously, or give up thinking after playing the same routine, close their eyes and concentrate on mowing the grass.

This is another design idea. Sleepwalking hopes to directly create a fresh sense of He Shuang with randomness, thus bypassing the hard-core and difficult-to-give-up feature of "players need to learn through constant failure" in fundamentalism Roguelike.

At this time, we should be able to understand more clearly the phrase "sweeping 1.4 billion dreams" when Sleepwalking was published. It doesn’t need many complicated and obscure rules and mechanisms, but it only needs to design different themes and then put them together and collide with each other. The "unrestricted" theme also allows Sleepwalking to give full play to this aspect.

Following this line of thinking, the next problem that Sleepwalking needs to solve is how to effectively show its strengths and let players try more diverse content.

There are still many details that can be polished in a test of Sleepwalking. For example, one of the two sides of the aforementioned "2+2=2*2" is that players will encounter "difficulty in choosing". Let me give an extreme example:

At this time, I thought of Hades, and only a small mechanism was needed to solve the problem.

A big problem in the combination of GaaS and Rougelite is the design of nurturing system: it can increase the depth of the game, but the overweight nurturing system will also make the game deteriorate.

"Sleepwalking" has not become a substantial development game like many Roguelite mobile games. Its cultivation system is very familiar, including role level, skill level, overlapping cards and equipment.

Players who are familiar with the two-dimensional card-drawing mobile game may have begun to feel bad, but in fact, except for the upgrade, the improvement of other cultivation elements is not too great: the full-level skill is only about 50% higher than the initial level, and the player’s most feared card stacking is mainly used to improve the rarity of the role’s corresponding BUFF, and the numerical value is not particularly obvious.

The test of Sleepwalking only lasted less than 4 days. Theoretically, the long-term gameplay does not belong to the focus of this test, but the new knowledge of the game still feels some ideas: grading the gameplay and making the gameplay with lower level become the cultivation process of the gameplay with higher level.

This "lower level" gameplay is the Roguelite main gameplay that we are all familiar with: destroying enemies in fixed-length checkpoints, managing BUFF and resources, and challenging the final BOSS. On the settlement page of the main game after customs clearance, players can choose to save the lineup status at customs clearance to form a "seal".

Imprinting can play a role in other gameplay. For example, there is only one BOSS in the actual process of a short material level. At this time, players only need to choose the pre-saved imprints to directly challenge with the customs clearance team.

This idea can be said to be multi-faceted: special levels create demand for engraving for players, so players get the motivation to play the main mode and explore new construction methods; After a difficult challenge, you can get a new upper limit of material unlocking, forming a spiral play curve.

In addition, Roguelike will force the player to know the progress in the game after a game, which sometimes makes the player feel unfinished-the mechanism of printing can solve this problem to some extent.

Sleepwalking doesn’t look like a game pieced together by randomly selecting several labels. Aauto Quicker’s "highest level" does have something.