Suzhou, China, Palo Alto, California, USA May 20, 2021/PRNewswire/-Genxi Biotechnology Group (NASDAQ: GRCL；; Genxi Bio, a global clinical biopharmaceutical company dedicated to developing efficient and economical cell therapy for cancer treatment, announced today that it will publish the latest clinical research results of a multi-center, first-time human trial on GC012F in the treatment of relapsed/refractory multiple myeloma during the annual meeting of American Society of Clinical Oncology (ASCO) in 2021 and the conference of European Hematology Association (EHA) in 2021.

GC012F is a BCMA/CD19 dual-target autologous CAR-T cell therapy developed based on the patented technology platform of Genxi Bio-FasTCAR, which has the advantage of "production can be completed the next day". At present, the candidate product is being evaluated in a phase I clinical trial initiated by researchers.

• By January 12, 2021, 19 patients with multiple myeloma were enrolled in the three dose groups of this study, of which the highest dose level was 3×10.^fiveCells/kg body weight, all the above patients meet the criteria of recurrence/refractory after multiple rounds of treatment. Subsequent patients (after the release of data at the ASH annual meeting in 2020) received the highest dose level of treatment.
• The early objective remission rate (ORR) was as high as 94.7%(18/19), and all the responses showed that excellent partial remission (VGPR) and even complete remission (SCR) were obtained. The data of all dose groups showed a rapid, in-depth and lasting therapeutic effect.
• All patients (n=9) who received treatment in the highest dose group achieved negative minimal residual lesions-complete remission (MRD- sCR) in a strict sense.
• Of the 19 patients, 18 (94.7%) belonged to the high-risk patients defined in mSMART 3.0 guidelines, and the median number of previous treatment lines was 5.
• 94.7%(18/19) patients have been exposed to PI, IMiD and at least the third treatment scheme, including anti-CD38 targeted therapy.
• The safety of GC012F is consistent with the previous observation results, and the main symptom is low-grade cytokine release syndrome (CRS)(84% patients are grade 1/2; 11% (n=2) patients were grade 3), and there was no grade 4 or 5 CRS；. No immune effector cell-related neurotoxicity (ICANS) was observed in 19 patients. Adverse events (TEAEs) occurred during treatment were mainly manifested as decrease of blood cell count and increase of AST. All TEAEs were relieved after standard treatment.
• The study will continue to evaluate the effectiveness and safety of GC012F in the treatment of patients.

"I am glad to see the mutual evidence between the follow-up of the initial patients and the treatment effect of the subsequent patients, which not only confirms the research results announced at the annual meeting of ASH last year, but also further clarifies the excellent safety and effectiveness of GC012F dual-targeted autologous CAR-T cell therapy, including for high-risk patients."Chief Medical Officer of Genxi BiologydoctorIt said: "High-risk patients are usually extremely difficult to treat, but all patients in the highest dose group in this study have reached the MRD negative sCR state and maintained a deep response for six months or even longer after receiving GC012F infusion. The above exciting research data bring brand-new hope to high-risk patients (including those who do not respond to the standard treatment plan). Next, we plan to promote this research on a global scale, including promoting it as a more preferred treatment option. I look forward to sharing more developments with you in the near future. "

GC012FClinical research initiated by researchers (IIT) Co-principal researcher, Professor Du Fu of shanghai changzheng hospital."Multiple myeloma (MM) is a malignant blood tumor that is extremely difficult to treat. There are about 750,000 patients with multiple myeloma worldwide.^[1]There are about 160,000 new patients every year.^[2]And it is on the rise year by year. Among them, high-risk patients account for 20%-30%.^[3]The prognosis is usually poor, accompanied by higher risk of early recurrence, shorter progression-free survival and overall survival. This time, we are pleased to see that the BCMA/CD19 dual-target autologous CAR-T cell therapy GC012F of Genxi Bio has shown excellent effectiveness and safety for the long-term follow-up results of patients with relapsed/refractory multiple myeloma. And thanks to the advantages of FasTCAR platform, the waiting time of clinical treatment has been significantly shortened, and the hope of life has been ignited for more patients. "

GC012FClinical research initiated by researchers (IIT) Co-principal researcher, Professor Fu Weijun of shanghai changzheng hospital.Said: "I am very happy to see that after we announced the first human trial data of GC012F in the form of oral report at the ASH meeting last year, this research has made positive progress again, and the previous results have been further verified; This also allows us to see the good application prospects of Ganxi Bio-FasTCAR platform and Dual CAR technology. With the deepening of research, the clinical benefits of this innovative BCMA/CD19 dual-targeted autologous CAR-T cell therapy for patients with multiple myeloma, especially high-risk patients, are constantly emerging. It is expected that this research will continue to achieve more results and strive to meet the urgent treatment needs of patients with recurrent/refractory multiple myeloma as soon as possible. "

Details of the electronic poster are as follows:

2021American Society of Clinical Oncology (ASCO) annual meeting

abstract8014：Long-term follow-up results of the first multicenter human trial of BCMA/CD19 dual-target CAR-T cell therapy GC012F for patients with relapsed or refractory multiple myeloma based on FasTCAR platform.

Poster release date:June 4, 2021

2021European hematology association (EHA2021) conference

abstractEP962：Long-term follow-up results of the first multicenter human trial of BCMA/CD19 dual-target CAR-T cell therapy GC012F for patients with relapsed or refractory multiple myeloma based on FasTCAR platform.

Poster release date:June 11th, 2021

About multiple myeloma

Multiple myeloma (MM) is the third most common malignant hematological tumor in the United States. Its tumor cells originated from bone marrow plasma cells, an immune cell responsible for secreting anti-infective antibodies. About 160,000 patients worldwide are diagnosed with multiple myeloma every year; In 2020, the United States is expected to have more than 32,000 confirmed patients. In recent years, although many progress has been made in the treatment of multiple myeloma, the clinical treatment effect is still unsatisfactory. International Myeloma Working Group (IMWG) and the consensus guidelines of Mayo ST Rating for Myeloma and Risk-Adapted Therapy (MSMART) classify patients with specific cytogenetic abnormalities or other abnormalities as high-risk patients, and this group accounts for 20-30% of all patients with multiple myeloma. High-risk patients with high risk of early recurrence, progression-free survival and short overall survival are considered as the most difficult patients with multiple myeloma, and usually have poor prognosis.

aboutGC012F

GC012F is a candidate product for dual-target autologous CAR-T therapy based on FasTCAR platform. At present, the candidate product is evaluating its safety and effectiveness in the treatment of multiple myeloma in a multi-center and phase I clinical trial initiated by researchers, covering many research centers in China. GC012F brings rapid, in-depth and lasting therapeutic effects to patients with multiple myeloma by simultaneously targeting the malignant plasma cell site expressing BCMA and the early progenitor cell site expressing CD19.　

aboutFasTCAR

FasTCAR is a technology platform with intellectual property rights of Genxi Bio, aiming at developing high-quality autologous CAR-T cell therapy. Preclinical studies show that the phenotype of CAR-T cells produced by FasTCAR technology platform is younger, the degree of depletion is lower, and the amplification ability, persistence, bone marrow migration ability and tumor cell clearance activity are enhanced. With the advantage of "completing production the next day", FasTCAR platform technology can greatly improve cell production efficiency, thus significantly reducing production costs and enabling cell therapy to benefit more cancer patients.

About genxi creatures

Genxi Biotechnology Group (Genxi Bio for short) is a global clinical biopharmaceutical company dedicated to the discovery and development of breakthrough cell therapy. Using its pioneering FasTCAR and TruUCAR technology platforms, Genxi Bio is developing a number of rich clinical cancer treatment product pipelines, both autologous and allogeneic. These products are expected to overcome the persistent major industry challenges of traditional CAR-T therapy, including long production time, poor production quality, high treatment cost and lack of effective treatment for solid tumors. To learn more about Genxi Bio, please visit www.gracellbio.com/ Concern LinkedIn account @GracellBio.

Warning statement about forward-looking statements

The statement in the press release about future expectations, plans, prospects and other non-historical facts may contain a "forward-looking statement" as defined in the Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements related to the expected transaction and completion time of this offering. These statements may, but do not necessarily, contain the following words and corresponding negative forms or similar words: purpose, expectation, belief, estimation, prediction, plan, possibility, prospect, plan, potential, conjecture, formulation, seeking, possibility, should and will. Due to various important factors, the actual results may be significantly different from the forward-looking statements, and there is no guarantee that any forward-looking statements will be realized. These important factors include the factors mentioned in the Risk Factors section of Genxi Bio’s recent annual report in Form 20-F, and the discussion on potential risks, uncertainties and other important factors in Genxi Bio’s subsequent report to the US Securities Regulatory Commission after the session. Any forward-looking statements in this statement only reflect the current expectations, and Genxi Bio has no responsibility to publicly update or review any forward-looking statements, whether based on new information, future events or other reasons. Readers are requested not to rely on forward-looking statements after the publication date of this press release.

Media contact

marvin.tang@gracellbio.com

Investor contact

gracie.tong@gracellbio.com

　

　　When it comes to pickup trucks, many people will think of camping conventions, desert challenges, cruises around the city and other projects, and this is also a pickup truck feast that many pickup truck owners enjoy. With the continuous enrichment of China’s material culture, in the pickup truck market, a group of people have gradually emerged, far away from the hustle and bustle of the city, driving pickup trucks to "have fun", forming a pickup truck culture and even a pickup truck community in nature.

　　

　　Moreover, pickup trucks are in line with the emerging cultural tourism culture in recent years, and all kinds of go on road trip infrastructure services for pickup truck owners have also become new business cards of the city. Great Wall Motor, which started as a pickup truck in China, has also "sniffed" this business opportunity for a long time. Its Great Wall Gun (parameter picture) is a brand that has brought the pickup truck culture in China to the extreme, and it is constantly sought after by the high-end market.

　　

　　Recently (March 12), the global version of the newly upgraded Great Wall gun pickup truck was launched, with the price range of 126,800-166,800 yuan. At this conference, Great Wall Gun also reached a strategic cooperation with China canoeing national team and Pathfinder brand to jointly build the "strongest ecological circle" of pickup truck culture.

　　It is worth noting that compared with the original model, the price of the new car has not increased, which further improves the cost performance. However, in terms of configuration, it has increased the heating of the rear seat, the thickening of the engine guard plate, and the blue/real orange two global pickup colors. And many other highlights.

　　So, to sum up, what are the highlights of this global version of the Great Wall Gun that has attracted market attention?

　　15 seconds new car analysis!

　　1. The selling price has not increased, which improves the cost performance.

　　2. Two new colors of "blue" and "true orange" are added.

　　3. Maximum cargo hold of the same class of 1520mmx1520mmx538mm and maximum wheelbase of the same class of 3230mm

　　4. Standard high-strength cage body, ACC and the latest intelligent driving control system, and 360 safety configuration without dead angle.

　　5, 2 years of zero-interest financial policy, and basic services are free for life.

　　

　　

　　In terms of appearance, the new car is equipped with a thicker chrome grille, a larger LOGO, and eagle-eye smart headlights, which have great visual impact. Two new color schemes, "blue" and "true orange", are also added.

　　

　　In terms of size, the largest cargo hold of the same class of 1520mmx1520mmx538mm and the largest wheelbase of the same class of 3230mm also make the global version of the pickup truck for the Great Wall cannon full of practicality as always.

　　

　　As for the interior, the soft interior covers the car everywhere, and the front and rear seats are heated, the rear elbow pillows, the cup holder, more than 100 noise reduction treatments and exclusive fragrance once again enhance the driving experience of the global version of the Great Wall Gun, making it one of the few pickup truck models with luxury configuration.

　　

　　In terms of configuration, all-liquid crystal virtual instrument, 9-inch central control touch screen, yacht-type bar and other scientific and technological applications are not absent. In addition, the global version of Great Wall Gun is also equipped with a new generation of intelligent network connection system. Users can realize air conditioning temperature adjustment, navigation settings, door and window opening, online payment and other applications through voice, and the intelligence of pickup trucks is greatly improved.

　　

　　Since the off-road attribute is emphasized, the safety of the global version of the Great Wall Gun has to be mentioned. In addition to "hard-core" safety equipment such as high-strength cage body, high-strength door anti-collision beam and double-layer anti-collision beam, the global version of Great Wall Gun is also equipped with the latest intelligent driving control system. For example, when driving at high speed, the ACC full-speed intelligent cruise system can not only follow the car, but also automatically slow down in corners; In the process of driving, the cooperation of the functions of parallel line assistance, lane keeping and lane departure warning can also make the safety 360 without dead ends.

　　

　　In terms of power, the global version of Great Wall Gun is equipped with a 2.0T gasoline/diesel engine, which is matched with ZF 8AT transmission. Among them, the former has a maximum power of 190 HP and a peak torque of 360 Nm; The latter has a maximum power of 163 HP and a peak torque of 400 Nm. With the help of TOD intelligent four-wheel drive, rear axle electronic differential system and multi-link rear suspension, the passability of the new car is also greatly improved.

　　

　　In the era of multi-purpose pickup truck 3.0, users’ demand for quality has been further stimulated. In this regard, Great Wall Gun announced that it has reached a strategic cooperation with China canoeing national team, and jointly launched a life adventure plan with Pathfinder brand to jointly build the "strongest ecological circle" of pickup truck culture.

　　

　　At present, for every two pickup trucks sold in China, one is the Great Wall! The market share of Great Wall pickup truck in domestic sales has reached 51%, and in 2018, when Great Wall pickup truck was just independent, its market share was only about 29%. It should be said that today’s Great Wall Gun has become a well-deserved "China No.1" pickup brand. In the global market, the Great Wall pickup truck has accumulated more than 1.9 million users.

　　

　　In addition, Great Wall Motor revealed that it will officially debut in China’s first full-size pickup truck at the Shanghai International Auto Show in April this year. The new car will be built by a tank platform with stronger power, higher reliability, intelligent off-road and other characteristics. The new car is worth the public’s expectation!

On the eve of New Year’s Day in 2024, the three-hour press conference of Xiaomi Automobile wrote a strong footnote for the automobile industry in China in 2023. Just like many press conferences in the Internet age, a series of classic quotations from Lei Jun, founder, chairman and CEO of Xiaomi Group, broke through one community after another and spread faster than technology and product content. Subsequently, all kinds of analytical articles are flying like snowflakes. However, how did the foreign media, which have been paying close attention to the development of electric vehicles in China in recent years, focus on the Xiaomi auto conference? What do they all pay attention to?

China’s technology giants want to enter the top five in the global car industry.

First of all, foreign media pay special attention to Xiaomi’s goal of "becoming one of the top five automakers in the world". In his report, Reuters used the word "quickly" for Xiaomi’s goal immediately after the release of the first electric car. CNN reported that Lei Jun announced that he hoped to achieve this goal in 15-20 years.

Why did Lei Jun put forward this goal? Why are foreign media so sensitive to Xiaomi’s vow to enter the "top five"? Lei Jun once said that the top five brands in the world will hold more than 80% of the shares when summing up Xiaomi’s entrepreneurial thinking. That is to say, it will only make sense if they finally enter the top five in the global industry and ship more than 10 million units a year. "This will be extremely cruel competition." Bloomberg commented that Lei Jun believes that Xiaomi can shake the transportation industry just like shaking the smartphone market ten years ago.

Secondly, the foreign media will also focus on the entry of electric vehicles by China technology enterprises. The Wall Street Journal reported: "Apple is being overtaken by China’s smartphone competitors in the automotive field. Huawei and Xiaomi have launched electric vehicles for use with mobile phones. " CNN wrote at the beginning of the article, "Just a few days after Huawei launched another electric car, Xiaomi launched its first electric car, which shows that the efforts of China technology giants to join the electric car competition have begun to bear fruit."

At the press conference, Lei Jun didn’t start talking about the "operating system" and ecological concepts that technology companies are good at. Instead, what people see is a "good student" Lei Jun, who talks about motor, battery and die casting. I have to say that this is very "millet" in itself. Because the development of Xiaomi itself is an exploration of "manufacturing industry in internet plus", whether it is a smart phone or a smart car, Lei Jun emphasizes the need to adhere to the "triathlon"-hardware, software and Internet services simultaneously. This is also the capability characteristic of China technology enterprises compared with foreign technology companies, which can integrate upstream and downstream industrial chains, quickly and massively transform technology into actual products, and achieve a good customer experience. Therefore, it is understandable that foreign media pay close attention to the electric vehicle manufacturing of China science and technology enterprises.

In addition, foreign media naturally have a good understanding of the natural advantages of Xiaomi’s car. Reuters noticed that SU7, Xiaomi’s first electric car, would share the operating system with Xiaomi’s mobile phone and other electronic devices, and thought it would be an advantage for Xiaomi to attract customers. The US Consumer News and Business Channel (CNBC) reported that Xiaomi is famous for its smart phones and household appliances, which is a potential advantage area for Xiaomi, and Xiaomi wants to create a "full ecology of people, cars and homes".

Hard-core technology shapes game breakers.

Reuters also mentioned the "super motor" technology introduced by Xiaomi Automobile, which can provide faster acceleration speed than Tesla and Porsche electric vehicles. At the press conference, Lei Jun said that the goal is to create a beautiful, easy-to-open, comfortable and safe mobile smart space, and to be a dream cars comparable to Porsche and Tesla. In the era of always expecting subversion, Xiaomi has found two benchmarking targets, which at first sounds like nothing new. However, it is not easy to do. This means that Xiaomi should make progress in major technologies that can be intuitively experienced by the market.

In the complex automobile research and development and production, Xiaomi first solved some core problems of electric vehicles and made breakthroughs in key technologies with suppliers. For example, accelerate performance. Among the five core technologies released by Xiaomi Automobile this time, the first one is the super motor developed by Xiaomi. The motor has three generations of synchronous operation, mature generation, research and development generation and pre-research generation. Among them, the V6/V6s motor with a speed of 21,000 rpm has been mass-produced, and the V8s motor with a speed of 27,200 rpm has been mass-produced. It will be put on the bus in 2025, and the Xiaomi next-generation super motor with a pre-research speed of 35,000 rpm has applied for a patent. Xiaomi SU7 is equipped with V6/V6s super motor, of which SU7 Max version adopts dual-motor all-wheel drive, and the zero-speed acceleration is as fast as 2.78 seconds.

Another example is the battery, the core component of electric vehicles. Xiaomi CTB integrated battery technology integration efficiency will reach 77.8%, which is the first battery cell inversion design with better safety system and endurance. The cruising range of the two versions of Xiaomi SU7 under CLTC condition is 668km and 800km respectively. Lei Jun said at the press conference that as an automobile manufacturer with a factory in the north, Xiaomi Automobile will challenge the winter battery life.

In addition, another technology that has been in the forefront of the world is the 9100t integrated large die-casting equipment cluster independently designed by Xiaomi and its Titan alloy independently developed. This high-end manufacturing will help Xiaomi Automobile to improve manufacturing efficiency and quickly occupy the market in the future.

Halfway through the conference, the release of intelligent driving and intelligent cockpit technology began slowly. Lei Jun once again mentioned the strategy of building a "full ecological scene of people and cars", and said that the essence of intelligent driving is artificial intelligence. In 2016, Xiaomi began to invest in artificial intelligence and proposed that perception is the foundation. Therefore, the self-developed adaptive zoom BEV technology, large road model and super-resolution occupation network technology adopted by Xiaomi SU7 are all aimed at improving the visibility accuracy, perception accuracy and control accuracy in different driving scenarios.

On the smart cockpit, based on Xiaomi 澎湃 OS operating system, Xiaomi SU7 has realized the comprehensive sharing ecology from hardware to software, which not only can realize the five-screen linkage in the car, but also can realize the seamless connection of the mobile phone and the deep adaptation of the car.

Xiaomi builds a car and takes advantage of China’s talent development.

From March 30, 2021, Lei Jun announced to build a car to Xiaomi Auto Conference, which lasted for 1003 days. Lei Jun promised that Xiaomi would invest 10 billion US dollars to build cars in the next decade, with an initial investment of 10 billion yuan, and repeatedly stressed that it would invest ten times in research and development. At present, Xiaomi Automobile has more than 3,400 engineers and thousands of first-class technical experts at home and abroad in key fields. This practice of concentrating first-class talents in the industry and quickly achieving key technological breakthroughs is also very small.

Among them, Lei Jun introduced the Xiaomi design team at the press conference, which was composed of Li Tianyuan, the world’s first China designer of BMW, Qiu Zhen, a former senior foreign affairs designer of Mercedes-Benz German headquarters, and Shin, a former senior interior designer of BMW. The average industry working experience of the team is over 10 years, young and with ideas. Xiaomi’s body design, wind resistance solution and laser radar design scheme come from the team’s pursuit of natural inspiration, and the low-carbon and environmental protection travel concept has been considered since the beginning of the car. At the same time, it reflects that China automobile industry has participated in the development of global automobile industry for many years, providing opportunities and soil for the global development of outstanding automobile talents. Now, these talents will also become a new generation of trendsetters, seize domestic opportunities and better realize their ambition to build cars.

It is understood that Xiaomi SU7 is expected to be mass-produced in the first half of 2024. Lei Jun said that with the comprehensive empowerment of industrial hard technology, intelligent soft technology and artificial intelligence, Xiaomi Automobile will completely redefine the technology stack of the automobile industry. At the same time, we will also pay attention to what changes will take place in people’s travel life with the listing of Xiaomi Automobile. It remains to be seen how Xiaomi will enable the Internet to empower automobile manufacturing.

Special planning

Audit | Lu Changyin

Edit |?Li xundian

　　Entrusted the owner of the lottery shop to buy lottery tickets on his behalf, but he won 14 million prizes. But when I wanted to get the lottery ticket, I found that the boss couldn’t contact me, and even the lottery shop was closed. Upon further inquiry, the winning lottery ticket went to the boss’s friend.

　　The boss took the lottery and ran away? Or do you want to swallow the grand prize? Who finally won the 14 million prize?

　　Yesterday, a reporter from qianjiang evening news came to this small lottery shop in Shengzhou. On November 10th, five days after closing, the lottery shop reopened. After this big prize storm, Xiao Xu, the post-90 s boss, was a little tired. He said, "If the sports lottery shop stops, I may never know for a lifetime, but I am willing to stand up and deal with this crisis."

　　Won more than 14 million yuan.

　　I can’t get the lottery ticket.

　　Things should start from November 5.

　　Mr. Sun, an old lottery player in Shengzhou, followed a group of lottery tickets for a long time, spending 218 yuan a week to follow 109 lottery tickets. Sometimes he doesn’t have time, he will entrust a nearby sports lottery station to buy it. On November 5, Mr. Sun WeChat entrusted Xiao Xu to buy tickets. Xiao Xu is 23 years old. He has just opened this sports lottery station for two months.

　　On the night of the Super Lotto, two of the lottery numbers purchased by Mr. Sun won the first prize, and the bonus for each note was 7114758 yuan. In this way, Mr. Sun won more than 14 million yuan.

　　Mr. Sun was so excited that he called Xiao Xu immediately. Xiao Xu also confirmed that Mr. Sun won the lottery. Who knows that after this call, Xiao Xu can’t contact and the store is closed.

　　Seeing that the prize is about to be redeemed, but the lottery ticket is not available, Mr. Sun is anxious.

　　There is only one lottery ticket.

　　There are two winners.

　　The lottery ticket that won the grand prize is in the hand of Mr. Ying, a friend of Xiao Xu. What’s going on?

　　The following is Xiao Xu’s self-report:

　　On the morning of November 3rd, Mr. Ying came to my shop. He only bought scratch music before, and this time he asked me how to buy the lotto. I recommend him to buy a set of numbers that Mr. Sun often calls. In the evening, we watched TV together. On November 4th, at about two o’clock in the morning, he gave me 220 yuan to buy lottery tickets. But the lottery machine was off at that time, so I told him to help him type out the lottery ticket the next day. Unfortunately, I forgot later.

　　On November 5, I asked Mr. Sun on WeChat as before if he wanted to type out the lottery ticket he had been following. Mr. Sun said yes, so I typed the ticket for him.

　　After the lottery that night, Mr. Sun called me, and I was very excited. But this time I remembered that I only had one set of lottery tickets.

　　I’m a little flustered, because it’s more than 10 million yuan after all, and we ordinary people can’t earn so much money in our lifetime.

　　Who will win the lottery? Mr. Ying told Xiao Xu that he had called and paid the money on the spot, so the lottery ticket belonged to him. So, Xiao Xu handed the lottery ticket to Mr. Ying that night.

　　Who should the lottery go to?

　　Shopkeepers, they asked seven lawyers.

　　Xiao Xu said that he later found that there were more than 20 people around the door of the store, and he panicked, so he turned off his mobile phone and the store was closed.

　　Here, Mr. Sun, who was in a hurry to get angry, consulted a lawyer, and the lawyer suggested applying to the court for property preservation.

　　On November 7, when Mr. Ying took the lottery ticket to win the prize, he found that it had been frozen.

　　For the ownership of the grand prize, the two began to negotiate.

　　Xiao Xu also clarified to us that he has been negotiating with two lottery buyers and has not run away. "When people see me close the door, they must think I’m looking for ‘ Tuo ’ Stealing the grand prize, or I ran away with the lottery ticket. In fact, the next day, I contacted Mr. Sun with my mother’s number and told the story, which was evidenced by the call record. "

　　Xiao Xu said that for this matter, he and Mr. Ying consulted different lawyers seven times. "Shengzhou consulted four and Hangzhou asked three."

　　Xiao Xu is concerned about whether he is responsible for this matter. What Mr. Ying asked is whether he can win the grand prize.

　　Lawyer: Let’s see whose evidence is reliable.

　　Who should win the grand prize? Let’s listen to the lawyer.

　　Lawyer Chen Yilai of Zhejiang Times Commercial Law Firm analyzed: Mr. Sun entrusted Xiao Xu to buy lottery tickets through WeChat, and the entrustment relationship was still established whether he paid or not. If Mr. Sun can’t get the lottery ticket, he can file a lawsuit, and the WeChat message between him and Xiao Xu can be used as electronic evidence.

　　What about Mr. Ying? According to Xiao Xu, Mr. Ying paid in cash at that time, accompanied by Mr. Ying’s wife and a friend, and there was no other physical evidence. The lawyer explained that the key evidence identification mainly lies in documentary evidence, and witness testimony has only an auxiliary role, while the effectiveness of interested witness testimony needs to be verified.

　　If Mr. Ying wants to get back the lottery prize, he can sue Xiao Xu and ask the other party to compensate according to the amount of the winning lottery ticket. This is a typical contract breach lawsuit. But effective and sufficient evidence must be provided.

　　Outcome: Who will get 14 million yuan?

　　On November 9th, the lawyers of Mr. Ying and Mr. Sun negotiated, and the lottery ticket went to Mr. Sun. After that, the lottery ticket was successfully redeemed and the sports lottery station reopened on the same day.

　　Mr. Ying, who passed the grand prize, said that his mood these days is like riding a roller coaster, going back and forth from the peak to the bottom countless times. However, he and Xiao Xu have been friends for many years. If they cut off contact for lottery tickets, it would not be worth the loss, so they have no intention to sue Xiao Xu.

　　Our reporter Wang Zifang Wen/photo

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

　　

　　　　　 First, drive an elevated road along Humin Road. 6 kilometers from exit to enter Shanghai to Kunming highway

　　Second, in Shanghai to Kunming Highway

　　1) Drive 430 meters along the Shanghai -Kunming Expressway. Hangzhou/G60/Ningbo/Xinzhuang direction, open a small right

　　2) Continue along Shanghai to Kunming Expressway 27. 6 kilometers straight into the Hangzhou Bay Ring Road Expressway

　　Third, Hangzhou Bay Wound Highway Expressway

　　Travel 52 along Hangzhou Bay Ring Road. 7 kilometers, go directly to Hangzhou, open a little bit of Shanghai to Kunming highway

　　Fourth, in Shanghai to Kunming Expressway.

　　Travel along Shanghai to Kunming highway. 3 kilometers, go directly to Hangzhou/ Qiandao Lake/ S2, and turn to Hangzhou -Ningbo Expressway

　　Fifth, Hangzhou -Ningu Highway

　　1) Drive along Hanging Highway 21. 9 kilometers directly to Hangzhou/Desheng Road, and it becomes a little bit of Disheng

　　2) Walk 610 meters along Desheng Road, and open a small right

　　Sixth, Zhejiang driving plan

　　1) Continue to run 840 meters along De Sheng, enter Disheng Fast from the entrance

　　2) Drive 680 meters along Desheng quickly, leave the slope from the airport exit

　　3) Drive 360 ??meters along the ramp and go straight into Dusheng East Road

　　4) 580 -meter driver along the Sheng Dong Road, turn left in front to enter the airport road

　　5) 3 drivers along the airport road. 7 kilometers, in the direction of the Chengdong Bridge Stadium, rotate the bridge slightly

　　6) Travel along the bridge 1. About 60 meters after 2 kilometers from the Hangzhou Criminal Investigation Building, go straight into the field

　　7) 2 drivers along the stadium road. Turn left to the ancient Xinhe Bridge at 9 kilometers and enter Western Road

　　8) 530 meters along the West Road of the Ring City, open the provincial roads and bridges into the provincial government

　　9) Drive 280 meters along the provincial government. Arrive at the end (on the right side of the road)

Mobile phone access　Shanghai local treasure first page

New youth

Always accompany you all the way

At 3:40 pm on November 29, the women’s basketball competition was held in the large playground, and the School of Mechanical and Electrical Engineering VS Materials and Environmental Engineering College.

At the beginning of the game, the basketball athletes of the Mechanical and Electrical Institute took the initiative to pass the ball with a good and skilled movement, and to force the rebound. Our team members quickly entered the state, and they were all heroic. On the court, you are fighting for me, you attacked me, and you have a skilled pitching. The pitching movements are handsome and neat. At the same time, the cheerleaders also shouted outside the court, and the atmosphere of the court was very active. In the end, the School of Mechanical and Electrical Engineering won the game at 25:19.

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After this basketball game, it not only enriched the students ‘extra -curricular life, but also strengthened the students’ awareness of exercising and solidarity and cooperation, allowing students to relax their body and mind in the intense study life, and felt the strength and warmth of the group’s groups. Essence I hope that our women’s basketball team members will be overwhelmed all the way in the next game and break the waves to win a better ranking!

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